{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:03:13Z","timestamp":1758474193655,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T00:00:00Z","timestamp":1509235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infections are important complications associated with allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Describing infection rates in low\u2010 and middle\u2010income countries provides data to infer efficacy of supportive care practices in these settings. In this retrospective cohort study, we included patients (age \u2264 18\u00a0years) who underwent a first allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> in a single center in Argentina between 1998 and 2016. The primary outcome was sterile site bacterial infection. Secondary outcomes were proven or probable invasive fungal infection, <jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content>, and infectious deaths. There were 68 allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> included in this analysis. Overall, 17 (25.0%) experienced at least one sterile site bacterial infection and 10 (14.7%) experienced at least one proven or probable invasive fungal infection. The <jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content> rate was 19.1%, and 3 (4.4%) patients died of infection. In a middle\u2010income country center in Argentina, pediatric allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> infection rates, <jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content>, and infection\u2010related mortality were comparable to high\u2010income countries. These data support continuation of allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> programs in similar resource\u2010limited settings provided that adequate supportive care and monitoring of outcomes can be performed.<\/jats:p>","DOI":"10.1111\/petr.13070","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T04:12:35Z","timestamp":1509336755000},"source":"Crossref","is-referenced-by-count":4,"title":["Early bacterial and fungal infection in children receiving allogeneic stem cell transplantation for acute lymphoblastic leukemia in Argentina"],"prefix":"10.1111","volume":"22","author":[{"given":"S.","family":"Gomez","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplantation Hospital de Ni\u00f1os Sor Mar\u00eda Ludovica  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Fynn","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hospital de Ni\u00f1os Sor Mar\u00eda Ludovica  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fernanda","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hospital de Ni\u00f1os Sor Mar\u00eda Ludovica  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cecilia","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Mycology Hospital de Ni\u00f1os Sor Mar\u00eda Ludovica  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-3091","authenticated-orcid":false,"given":"L.","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401939"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808273390907"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401973"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110169"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.09.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.132"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.08.035"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.08.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705690"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.10.024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12176"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2005.00088.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12175"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20130009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjhh.2014.11.012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4067\/S0716-10182013000200010","article-title":"Epidemiology of febrile neutropenia in adult patients with hematologic neoplasms in a period of 26\u00a0months in Hospital Pablo Tobon Uribe, Colombia","volume":"30","author":"Madrid C","year":"2013","journal-title":"Rev Chilena Infectol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.9747"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00197-7"},{"key":"e_1_2_8_22_1","first-page":"89","article-title":"Epidemiology and risk factors for bloodstream infections after allogeneic hematopoietic stem cell transplantation","volume":"30","author":"Cappellano P","year":"2007","journal-title":"New Microbiol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/322604"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2014.985709"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pis044"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.136"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.01.015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24559"},{"key":"e_1_2_8_29_1","unstructured":"The World Bank Group.Data for Upper middle income Argentina.2017;http:\/\/data.worldbank.org\/?locations=XT-AR. 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