{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:26:58Z","timestamp":1785342418497,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antibodies has been shown to be a significant risk factor for graft failure. In 2008, we instituted a routine protocol of standardized monitoring and treatment of dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> in pediatric kidney transplant recipients. Of 67 first\u2010time pediatric kidney transplant recipients, 26 (38%) developed dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> after 1.36 (<jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content> 1\u20102.14) years. Coefficient of variance of tacrolimus, a surrogate marker of non\u2010adherence, was found to be the single most important risk factor for dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> development. Overall, there was a significant reduction in dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> with treatment in 19 (76%) children. No difference in graft survival and estimated glomerular filtration rate was noted between dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> negative and those treated for dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>. There was an increased risk of hospitalization in those treated for dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>. This study suggests that early detection and treatment of dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> can help to prevent graft failure and preserve graft function in the short term. Future studies and longer follow\u2010up are needed to fully elucidate the effect of early detection and treatment of dn<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> in pediatric kidney transplant recipients.<\/jats:p>","DOI":"10.1111\/petr.13108","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T16:27:48Z","timestamp":1516638468000},"source":"Crossref","is-referenced-by-count":14,"title":["Results of early treatment for de novo donor\u2010specific antibodies in pediatric kidney transplant recipients in a cross\u2010sectional and longitudinal cohort"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-2882","authenticated-orcid":false,"given":"Olga","family":"Charnaya","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology Children's National Health System  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamir","family":"Tuchman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Children's National Health System  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Moudgil","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Children's National Health System  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03283.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12203"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00360.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200210270-00025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.81"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04013.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04251.x"},{"key":"e_1_2_7_9_1","first-page":"515","article-title":"Cytotoxic antibodies monitoring in kidney transplantation\u2013their clinical relevance and challenges","volume":"53","author":"Gingu C","year":"2012","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31827d62e3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014080837"},{"key":"e_1_2_7_12_1","first-page":"351","article-title":"De novo donor specific antibodies and patient outcomes in renal transplantation","author":"DeVos JM","year":"2011","journal-title":"Clin Transpl"},{"key":"e_1_2_7_13_1","first-page":"395","article-title":"Targeted monitoring of donor\u2010specific HLA antibodies following renal transplantation","author":"Almeshari K","year":"2011","journal-title":"Clin Transpl"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2010.00955.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31827a19cc"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12775"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13295"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01688.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02159.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03840.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000055833.65192.3B"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31817c4cb8"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12707"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2101-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070663"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12247"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12859"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000128"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13067"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01299.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31822dc34f"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3422-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001040"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12637"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07111009"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2011.01.001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302506"},{"key":"e_1_2_7_38_1","first-page":"359","article-title":"Clinical significance of post kidney transplant de novo DSA in otherwise stable grafts","author":"Cooper JE","year":"2011","journal-title":"Clin Transpl"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000170864"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14229"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:08:09Z","timestamp":1695503289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/petr.13108"],"URL":"https:\/\/doi.org\/10.1111\/petr.13108","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]},"article-number":"e13108"}}