{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:30:16Z","timestamp":1792798216811,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"United Network for Organ Sharing (UNOS)","award":["234-2005-370011C"],"award-info":[{"award-number":["234-2005-370011C"]}],"id":[{"id":"https:\/\/ror.org\/02t882k81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>\n \n PDDTE<\/jats:styled-content>\n are tracked by the\n OPTN<\/jats:styled-content>\n Ad Hoc\n DTAC<\/jats:styled-content>\n . Specific evaluation of potential transmissions from pediatric deceased donors or the impact of donor\u2010derived disease transmissions to pediatric organ recipients has not been previously undertaken.\n PDDTE<\/jats:styled-content>\n reported to the\n DTAC<\/jats:styled-content>\n between 2008 and 2013 were reviewed, characterized as proven, probable, possible,\n IWDT<\/jats:styled-content>\n , unlikely, or excluded for both the whole event and each individual recipient. Pediatric donors and recipients were defined as being 0\u201017\u00a0years of age. Analysis was undertaken to characterize potential disease transmission from pediatric donors to adult or pediatric recipients and also to evaluate potential transmission from all donors to pediatric recipients. P\/P cases were further analyzed. A total of 5238 pediatric deceased US donors accounted for 17\u00a0456 organ transplants during the study period; 103\n PDDTE<\/jats:styled-content>\n reports arose from these donors (2.0%).\n PDDTE<\/jats:styled-content>\n were characterized as P\/P (15%), possible (13%),\n IWDT<\/jats:styled-content>\n (9%), unlikely, and excluded (63%). Disease was transmitted to 22 of 54 potentially exposed (adult and pediatric) recipients with six attributable deaths. An infectious pathogen accounted for 13\/15 of the P\/P\n PDDTE<\/jats:styled-content>\n associated with pediatric donors, affecting 19 of 50 potentially exposed recipients and resulting in five deaths. Four separate viral pathogens from six donors accounted for P\/P transmissions to 11 recipients with the unanticipated transmission of\n CMV<\/jats:styled-content>\n most common. No pediatric donor transmitted\n HIV<\/jats:styled-content>\n ,\n HBV<\/jats:styled-content>\n , or\n HCV<\/jats:styled-content>\n . Bacteria, fungi, and parasites accounted for three (all staphylococci), three (Zygomycetes and\n Histoplasma<\/jats:italic>\n ), and two (both\n Toxoplasma<\/jats:italic>\n ) P\/P transmissions from seven donors, respectively. From the recipient side, 11\/11,188 pediatric recipient deceased and living donor transplants during the study period were associated with a P\/P\n PDDTE<\/jats:styled-content>\n (<0.1%) with infectious pathogens accounting for 9\/11 P\/P events. Infections were split among pathogen categories (bacteria 2, viruses 3, parasites 3, and fungi 1). Reporting rates of\n PDDTE<\/jats:styled-content>\n involving pediatric donors were very low and similar to rates from all donors, with resulting P\/P transmissions occurring in only 0.1% of exposed recipients, but transmissions were associated with six deaths. Rates of P\/P transmission to pediatric recipients from any donor (<0.1%) were also very low and similar to that of all recipients. Additional studies are needed to compare the pattern and outcome of donor\u2010derived disease transmission from and to pediatric and adult donor and recipients.\n <\/jats:p>","DOI":"10.1111\/petr.13115","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T09:06:35Z","timestamp":1516179995000},"source":"Crossref","is-referenced-by-count":23,"title":["Pediatrics and donor\u2010derived disease transmission: The\n US OPTN<\/scp>\n experience"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-2894","authenticated-orcid":false,"given":"Michael","family":"Green","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Departments of Pediatrics and Surgery University of Pittsburgh School of Medicine Children's Hospital of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shandie","family":"Covington","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Taranto","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian G.","family":"Michaels","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Departments of Pediatrics and Surgery University of Pittsburgh School of Medicine Children's Hospital of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Kaul","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Michigan Medical Center Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02700.x"},{"key":"e_1_2_7_3_1","unstructured":"Ad Hoc Disease Transmission Advisory Committee.http:\/\/optn.transplant.hrsa.gov\/members\/committeesDetail.asp?ID=95. Accessed September 19 2014."},{"key":"e_1_2_7_4_1","unstructured":"OPTN Policy 15.4.http:\/\/optn.transplant.hrsa.gov\/policiesAndBylaws\/policies.asp. Accessed September 19 2014."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000584"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03597.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022987"},{"key":"e_1_2_7_9_1","first-page":"1021","article-title":"West Nile virus infections in organ transplant recipients\u2010New York and Pennsylvania","volume":"54","author":"Centers for Disease Control and Prevention (CDC)","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"5","key":"e_1_2_7_10_1","first-page":"268","article-title":"Project NOTIFY: a global database of serious adverse events and reactions in organs, tissues and cells","volume":"13","author":"Ison M","year":"2013","journal-title":"Am J Transplant"},{"key":"e_1_2_7_11_1","volume-title":"A Decade of Donor\u2010Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee","author":"Kaul D","year":"2016"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T10:30:43Z","timestamp":1695724243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,17]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/petr.13115"],"URL":"https:\/\/doi.org\/10.1111\/petr.13115","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,17]]},"article-number":"e13115"}}