{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:49:10Z","timestamp":1780375750387,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content> is the most common malignant liver neoplasm in children. The etiology of <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content> is largely unknown but there are certain syndromes, such as Beckwith\u2010Wiedemann syndrome, that have been clearly associated with an increased incidence of this malignancy. <jats:styled-content style=\"fixed-case\">EBS<\/jats:styled-content>, also known as prune belly syndrome, is a congenital anomaly characterized by lax abdominal musculature, bilateral cryptorchidism requiring, in some cases, hemodialysis due to significant kidney and urinary tract dysfunctions. Despite an improvement on the survival rates of patients with advanced\u2010stage <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content>, the presence of concomitant end\u2010stage renal disease that occurs in patients with <jats:styled-content style=\"fixed-case\">EBS<\/jats:styled-content> constitutes a therapeutic challenge for the clinician not only due to the use of nephrotoxic chemotherapy but also due to the potential need for multi\u2010organ transplant. We report case of a 2\u2010year\u2010old male patient with <jats:styled-content style=\"fixed-case\">EBS<\/jats:styled-content> diagnosed with stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>, metastatic <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content> successfully treated with multi\u2010agent chemotherapy while on dialysis whom then underwent a simultaneous liver\u2010kidney transplant followed by adjuvant chemotherapy. Ultimately, the patient achieved cancer remission with normalization of his renal function. Our report emphasizes that patients with <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content> in the setting of <jats:styled-content style=\"fixed-case\">EBS<\/jats:styled-content> will not only require careful kidney function monitoring while receiving chemotherapy, but they might also need to undergo multi\u2010organ transplantation in order to achieve adequate cancer control and also normalization of their kidney function. Awareness of this unusual association calls for further investigation to potentially establish a genetic association between these two disease processes.<\/jats:p>","DOI":"10.1111\/petr.13123","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:12:22Z","timestamp":1516633942000},"source":"Crossref","is-referenced-by-count":4,"title":["Pediatric patient with end\u2010stage kidney disease secondary to Eagle\u2010Barrett syndrome and metastatic unresectable hepatoblastoma treated successfully with chemotherapy and liver\u2010kidney transplant"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-4438","authenticated-orcid":false,"given":"Daniel","family":"Ortiz","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Miami\u2010Holtz Children's Hospital  Miami FL USA"},{"name":"Division of Pediatric Hematology\u2010Oncology University of Miami\u2010Miller School of Medicine  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avis","family":"Harden","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Miami\u2010Holtz Children's Hospital  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando F.","family":"Corrales\u2010Medina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Miami\u2010Holtz Children's Hospital  Miami FL USA"},{"name":"Division of Pediatric Hematology\u2010Oncology University of Miami\u2010Miller School of Medicine  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Saigal","sequence":"additional","affiliation":[{"name":"Section of Pediatric Radiology Department of Radiology University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin","family":"Tekin","sequence":"additional","affiliation":[{"name":"Division of Liver\/GI Transplantation Department of Surgery Miami Transplant Institute University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Miami\u2010Holtz Children's Hospital  Miami FL USA"},{"name":"Division of Pediatric Gastroenterology Miami Transplant Institute University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1874-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50375"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.22953"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2016.04.01"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0361-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp598"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.12.032"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70008-3"},{"key":"e_1_2_5_10_1","first-page":"229","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Zimmerman A","year":"2010"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80297-5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.09.029"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:09:00Z","timestamp":1695503340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/petr.13123"],"URL":"https:\/\/doi.org\/10.1111\/petr.13123","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]},"article-number":"e13123"}}