{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:49:48Z","timestamp":1781617788860,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>EBV<\/jats:styled-content>\u2010CTL<\/jats:styled-content> immunotherapy targets EBV<\/jats:styled-content> antigens expressed by tumor cells in PTLD<\/jats:styled-content>. Data on outcome of EBV<\/jats:styled-content>\u2010CTL<\/jats:styled-content> in pSOT<\/jats:styled-content> patients are limited. The aim of the study is to describe our experience with allogeneic, third\u2010party EBV<\/jats:styled-content>\u2010CTL<\/jats:styled-content> for the treatment of PTLD<\/jats:styled-content> in pSOT<\/jats:styled-content> patients in a single tertiary center. Retrospective review was performed of all pSOT<\/jats:styled-content> patients who received EBV<\/jats:styled-content>\u2010CTL<\/jats:styled-content> for PTLD<\/jats:styled-content>. PTLD<\/jats:styled-content> was diagnosed using World Health Organization histologic criteria. EBV<\/jats:styled-content>\u2010CTL<\/jats:styled-content>s were derived from human leukocyte antigen\u2010typed, EBV<\/jats:styled-content>\u2010seropositive third\u2010party donors, and cryopreserved and maintained by an accredited national blood transfusion service. Ten patients received EBV<\/jats:styled-content>\u2010CTL<\/jats:styled-content> for histologically proven PTLD<\/jats:styled-content> from 1999 to 2016 following liver (n=5), combined intestinal\/liver (n=4), and liver\/kidney (n=1) transplantation. PTLD<\/jats:styled-content> occurred at median age of 40\u00a0months (range: 12\u2010144) and median post\u2010transplant interval of 8\u00a0months (range: 2\u2010107). Seven had monomorphic, two had polymorphic, and one had Hodgkin\u2010type PTLD<\/jats:styled-content>. All were of B\u2010cell origin and EBV<\/jats:styled-content>\u2010positive on histology. EBV<\/jats:styled-content>\u2010CTL<\/jats:styled-content> achieved an overall remission rate of 80% (8 of 10). Transient adverse effects included fever, tachycardia, and vomiting. None developed graft\u2010versus\u2010host disease or opportunistic infections. EBV<\/jats:styled-content>\u2010CTL<\/jats:styled-content> is an effective treatment for PTLD<\/jats:styled-content> in pSOT<\/jats:styled-content> patients, with good remission rate and minimal toxicity.<\/jats:p>","DOI":"10.1111\/petr.13133","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T05:52:40Z","timestamp":1517464360000},"source":"Crossref","is-referenced-by-count":50,"title":["Cytotoxic T\u2010lymphocyte therapy for post\u2010transplant lymphoproliferative disorder after solid organ transplantation in children"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-0267","authenticated-orcid":false,"given":"Fang Kuan","family":"Chiou","sequence":"first","affiliation":[{"name":"Liver Unit (Including Small Bowel Transplantation) Birmingham Women's and Children's Hospital Foundation NHS Trust Birmingham UK"},{"name":"Paediatric Gastroenterology KK Women's and Children's Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue V.","family":"Beath","sequence":"additional","affiliation":[{"name":"Liver Unit (Including Small Bowel Transplantation) Birmingham Women's and Children's Hospital Foundation NHS Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen M.","family":"Wilkie","sequence":"additional","affiliation":[{"name":"Scottish National Blood Transfusion Service The Jack Copland Centre Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Scottish National Blood Transfusion Service Royal Infirmary Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Morland","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Birmingham Women's and Children's Hospital Foundation NHS Trust Birmingham 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