{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:43:08Z","timestamp":1772412188076,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maintaining fluid balance, pre\u2010 and post\u2010MA\u2010HCT is essential and usually requires frequent administration of diuretics. Hepatic sinusoidal obstructive syndrome is potentially life\u2010threatening, especially when associated with <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> and MOF. This study describes six patients who developed <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> and diuretic\u2010resistant FO who subsequently underwent CRRT using standardized management guidelines for fluid balance post\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. Retrospective chart review was done for <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> patients between September 2011 and October 2013 at a tertiary care children's hospital. Thirty\u2010four patients underwent <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> in the study period. Six patients had <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> complicated by diuretic\u2010resistant <jats:styled-content style=\"fixed-case\">FO<\/jats:styled-content> and underwent <jats:styled-content style=\"fixed-case\">CRRT<\/jats:styled-content>. Defibrotide was used in three patients. Median time on <jats:styled-content style=\"fixed-case\">CRRT<\/jats:styled-content> was 10.5\u00a0days. Sixty\u2010six percent (N\u00a0=\u00a04 of 6) of patients had full resolution of <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> symptoms with a mortality rate of 34% (N\u00a0=\u00a02 of 6). Among patients who had full recovery of <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> symptoms, one patient developed <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>, end\u2010stage renal diseases and underwent kidney transplantation 34\u2010months post\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. Thus, of six included patients, two died and one developed <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> with only 50% (N\u00a0=\u00a03 of 6) good outcome. Use of a standardized, evidence\u2010based fluid balance protocol and early initiation of <jats:styled-content style=\"fixed-case\">CRRT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> was associated with good outcomes.<\/jats:p>","DOI":"10.1111\/petr.13139","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T05:52:46Z","timestamp":1517464366000},"source":"Crossref","is-referenced-by-count":22,"title":["The role of continuous renal replacement therapy in the management of acute kidney injury associated with sinusoidal obstruction syndrome following hematopoietic cell transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3892-8376","authenticated-orcid":false,"given":"Rupesh","family":"Raina","sequence":"first","affiliation":[{"name":"Pediatric Nephrology Akron Children's Hospital  Akron OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada A.","family":"Abusin","sequence":"additional","affiliation":[{"name":"Pediatric Bone Marrow Transplant University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Vijayaraghavan","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Akron General\/Akron Nephrology Associates  Akron OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery J.","family":"Auletta","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplant Program Nationwide Children's Hospital Ohio State University College of Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Cabral","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplant Program Rainbow Babies and Children's Hospital  Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Hashem","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplant Program Nationwide Children's Hospital Ohio State University College of Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Rainbow Babies and Children's Hospital  Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth R.","family":"Cooke","sequence":"additional","affiliation":[{"name":"Department of Oncology, Pediatric Blood and Marrow Transplantation Program The Sidney Kimmel Cancer Center Johns Hopkins University  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolla F.","family":"Abu\u2010Arja","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplant Program Nationwide Children's Hospital Ohio State University College of Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12483"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.03.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.12.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.08.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12840"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1309"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.07.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.208"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01900214"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1313-z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.349"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.06.006"},{"issue":"12","key":"e_1_2_8_14_1","article-title":"Strategies 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