{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T18:31:40Z","timestamp":1786818700751,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K16502"],"award-info":[{"award-number":["JP17K16502"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26861036"],"award-info":[{"award-number":["JP26861036"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate the significance of post\u2010transplant <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> as a predictor of liver fibrosis during long\u2010term follow\u2010up after pediatric <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. We evaluated the histological findings in 18 <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients who underwent liver biopsy after <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> screening. Liver fibrosis was scored based on the METAVIR fibrosis staging. Patients were divided into 2 groups based on histological findings, and clinical characteristics among patients with liver fibrosis were assessed. Of 18 patients, 7 were included in the fibrosis group. No significant between\u2010group differences were found regarding peritransplant characteristics, including age, sex, primary disease, <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> incompatibility, and immunosuppressive regimen. Episodes of acute rejection and non\u2010adherence to immunosuppressive drugs were comparable between both groups. The <jats:styled-content style=\"fixed-case\">MFI<\/jats:styled-content> for anti\u2010<jats:styled-content style=\"fixed-case\">DR DSA<\/jats:styled-content> and positive rate were significantly higher in the fibrosis group (1655 vs 216; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.019, 86% vs 27%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012, respectively). <jats:styled-content style=\"fixed-case\">MFI<\/jats:styled-content> for anti\u2010<jats:styled-content style=\"fixed-case\">DQ DSA<\/jats:styled-content> was higher in the fibrosis group, but non\u2010significantly (2052 vs 384; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.46). Post\u2010transplant anti\u2010<jats:styled-content style=\"fixed-case\">DR DSA<\/jats:styled-content> is associated with graft fibrosis during long\u2010term follow\u2010up. This finding seems useful for the implementation of valid histological examinations of liver grafts for patients with higher <jats:styled-content style=\"fixed-case\">MFI<\/jats:styled-content>, especially for anti\u2010<jats:styled-content style=\"fixed-case\">DR DSA<\/jats:styled-content>, after pediatric <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.13169","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:31:34Z","timestamp":1521117094000},"source":"Crossref","is-referenced-by-count":32,"title":["Association of post\u2010transplant donor\u2010specific <scp>HLA<\/scp> antibody with liver graft fibrosis during long\u2010term follow\u2010up after pediatric liver transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0607-8250","authenticated-orcid":false,"given":"Kazuaki","family":"Tokodai","sequence":"first","affiliation":[{"name":"Department of 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Pathology Tohoku University Graduate School of Medicine  Sendai 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