{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:41:05Z","timestamp":1760985665412,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Miller Pharmacal Group"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>We sought to investigate whether magnesium oxide bound to soy protein (MGP<\/jats:styled-content>) increases serum magnesium concentrations with less diarrhea compared to commonly prescribed magnesium salts. Subjects were switched to MGP<\/jats:styled-content> at a near\u2010equivalent daily elemental magnesium dose. Mean serum magnesium levels were compared. If magnesium levels remained <1.7\u00a0mg\/dL<\/jats:styled-content> after switching to MGP<\/jats:styled-content>, subjects were enrolled into Part 2 and received a one\u2010time MGP<\/jats:styled-content> dose adjustment. The MGP<\/jats:styled-content> daily dose was increased by 266\u00a0mg. For both parts 1 and 2, subjects recorded the number and quality of their stools to assess gastrointestinal (GI<\/jats:styled-content>) tolerability of MGP<\/jats:styled-content>. Twelve pediatric kidney transplant recipients completed Part 1. Mean serum magnesium levels increased from 1.61 (SD<\/jats:styled-content> 0.1) on standard MG<\/jats:styled-content> to 1.69 (SD<\/jats:styled-content> 0.1); t<\/jats:italic>(11) = 2.6, P<\/jats:italic> = .02 on MGP<\/jats:styled-content>. Five subjects completed Part 2, and all achieved serum magnesium \u22651.7\u00a0mg\/dL<\/jats:styled-content> (mean 1.75\u00a0mg\/dL<\/jats:styled-content>, SD<\/jats:styled-content> 0.06; t<\/jats:italic>(4) = 2.7, P<\/jats:italic> = .06). Subjects reported the same number of, but looser bowel movements with MGP<\/jats:styled-content>; however, individuals did not perceive intolerable GI symptoms with MGP<\/jats:styled-content> therapy and all chose to remain on MGP<\/jats:styled-content> at the end of the study. At an equivalent mg\/kg\/d dose of elemental magnesium, serum magnesium levels on MGP<\/jats:styled-content> were significantly higher.<\/jats:p>","DOI":"10.1111\/petr.13170","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T07:21:40Z","timestamp":1522135300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and tolerability of magnesium plus protein for managing hypomagnesemia in pediatric kidney transplant patients"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-4439","authenticated-orcid":false,"given":"Teresa V.","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Pharmacy: Clinical and Administrative Sciences The University of Oklahoma Health Sciences Center Oklahoma City OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Neely","sequence":"additional","affiliation":[{"name":"College of Pharmacy: Office of Instructional Science and Assessment The University of Oklahoma Health Sciences Center Oklahoma City OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Turman","sequence":"additional","affiliation":[{"name":"Department of Nephrology Phoenix Children's Hospital Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1111\/j.1600-6143.2009.02752.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1002\/lt.22146"},{"key":"e_1_2_7_4_1","first-page":"S194","article-title":"Assessment of magnesium status for diagnosis and therapy","volume":"23","author":"Elin RJ","year":"2010","journal-title":"Magnes Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1681\/ASN.V1071616","article-title":"Hypomagnesemia","volume":"10","author":"Agus ZS","year":"1999","journal-title":"J Am Soc Nephrol"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1007\/s00467-016-3571-6"},{"issue":"5","key":"e_1_2_7_7_1","first-page":"468","article-title":"Lower serum magnesium 1\u2010year post\u2010transplantation is associated with decreased graft survival in renal transplant recipients","volume":"13","author":"Nihei C","year":"2013","journal-title":"Am J Transplant"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1016\/j.trre.2015.05.002"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1097\/00007890-200209270-00009"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1056\/NEJM199104113241502"},{"unstructured":"MG plus protein magnesium supplement. Miller Pharmacal Group Inc.http:\/\/www.mgplusprotein.com\/index.html. Updated May 17 2006. Accessed January 5 2017.","key":"e_1_2_7_11_1"},{"unstructured":"Magnesium (Oral). Drug facts and comparisons. Facts & Comparisons [database online]. St. Louis MO: Wolters Kluwer Health Inc.; October 2016. Accessed January 5 2017.","key":"e_1_2_7_12_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.3109\/00365529709011203"},{"key":"e_1_2_7_14_1","first-page":"124","article-title":"Use of a novel stool scoring system for assessing bowel habits and laxatives use amongst older people\u2010a pilot study in Kingston, Ontario","volume":"1","author":"Wijeratne R","year":"2013","journal-title":"J Gen Pract"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1111\/j.1399-3046.2012.01727.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.3109\/0886022X.2014.917561"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1097\/01.ASN.0000113318.56023.B6"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1111\/j.1432-2277.2003.tb00267.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1097\/00045391-200109000-00008"},{"key":"e_1_2_7_20_1","first-page":"215","article-title":"Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg\u2010depleted rats using a stable isotope approach","volume":"18","author":"Coudray C","year":"2005","journal-title":"Magnes Res"},{"doi-asserted-by":"publisher","key":"e_1_2_7_21_1","DOI":"10.1080\/07315724.2004.10719416"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:34:19Z","timestamp":1695494059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,27]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/petr.13170"],"URL":"https:\/\/doi.org\/10.1111\/petr.13170","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2018,3,27]]},"assertion":[{"value":"2018-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13170"}}