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It poses a management challenge when hyperhydration and bladder irrigation do not result in clinical improvement as desired. The data regarding use of hyperbaric oxygen therapy (<jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content>2) as an early treatment modality in this clinical setting are limited. We present 2 cases, that were refractory to hyperhydration and bladder irrigation but responded to <jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content>2. They were treated with 20\u201030 daily sessions over weekdays with 100% oxygen for 90\u00a0minutes at 2 atmospheric pressure units (2 <jats:styled-content style=\"fixed-case\">atm<\/jats:styled-content>). Both patients reported improved symptoms within the first 15 sessions, and hematuria diminished by 20 sessions. Hyperbaric oxygen is a less invasive, outpatient therapy that is effective for treatment of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> and is tolerated well by young patients.<\/jats:p>","DOI":"10.1111\/petr.13171","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T09:30:49Z","timestamp":1521797449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hyperbaric oxygen as a treatment modality in cyclophosphamide\u2010induced hemorrhagic cystitis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-5705","authenticated-orcid":false,"given":"Dominder","family":"Kaur","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology &amp; BMT Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakila 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