{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T09:37:25Z","timestamp":1776591445701,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment of <jats:styled-content style=\"fixed-case\">SRNS<\/jats:styled-content> is a challenge. Antiproliferative agents and depleting antibodies have been reported to be effective. However, these agents are not always successful, and use of ofatumumab could provide a different treatment option. Our patient was diagnosed with a <jats:styled-content style=\"fixed-case\">SRNS<\/jats:styled-content> at 5\u00a0years of age. She developed <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>, with <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>. This was cause for a first renal transplantation. The <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> relapsed, leading to loss of the graft, and a second renal transplantation was performed. Due to the recurrence of the <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IA<\/jats:styled-content>ds were initiated and led to a complete remission. Our patient remained dependent on <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>ds, however, despite treatments with calcineurin inhibitors, corticosteroids, rituximab, and abatacept. Ofatumumab was introduced and led to a remission, thus allowing cessation of the <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>d treatment. Another infusion of ofatumumab was administered 8\u00a0months after the last one, due to the recurrence of the <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> and a renewed increase in B cells. Although it did not result in a complete remission, the proteinuria was stabilized in the absence of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>ds. Ofatumumab may be an alternative treatment for post\u2010transplantation rituximab\u2010resistant <jats:styled-content style=\"fixed-case\">SRNS<\/jats:styled-content>, although this needs to be confirmed by further studies.<\/jats:p>","DOI":"10.1111\/petr.13175","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T09:38:01Z","timestamp":1521797881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ofatumumab in post\u2010transplantation recurrence of a pediatric steroid\u2010resistant idiopathic nephrotic syndrome"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1342-3534","authenticated-orcid":false,"given":"Josselin","family":"Bernard","sequence":"first","affiliation":[{"name":"Pediatric Department University Hospital of Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Bruel","sequence":"additional","affiliation":[{"name":"Pediatric Department University Hospital of Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Allain\u2010Launay","sequence":"additional","affiliation":[{"name":"Pediatric Department University Hospital of Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Dantal","sequence":"additional","affiliation":[{"name":"Nephrology and Immunology Department University Hospital of Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwenaelle","family":"Roussey","sequence":"additional","affiliation":[{"name":"Pediatric Department University Hospital of Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1947-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc063706"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08500815"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60541-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.27.9836"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1308488"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1137-6"},{"key":"e_1_2_6_9_1","first-page":"17","article-title":"Management of recurrent nephrotic syndrome after kidney transplantation in children","volume":"46","author":"Cochat P","year":"1996","journal-title":"Clin Nephrol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401063300102"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2747-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304572"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015091002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3621-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3498-y"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-210208"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002231"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13355"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:35:07Z","timestamp":1695494107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/petr.13175"],"URL":"https:\/\/doi.org\/10.1111\/petr.13175","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,23]]},"assertion":[{"value":"2018-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13175"}}