{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:18:54Z","timestamp":1788556734938,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> is a serious complication of allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. To characterize the incidence, risk factors, and clinical outcomes of post\u2010<jats:styled-content style=\"fixed-case\">HSCT BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, we retrospectively analyzed 112 patients who underwent one or more allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>s at our hospital between 2001 and 2017. Twenty underwent second or third <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> thereafter. Ten patients developed <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> at a median of 30\u00a0days after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. The 100\u2010day cumulative incidences of grade 0\u20104 and grade 2\u20104 <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> were 7.8% and 6.2%, respectively. <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>s performed in 2011\u20102017 associated with significantly higher 100\u2010day cumulative incidence of grade 2\u20104 <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (14.0%) than <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>s performed in 2001\u20102010 (1.3%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004). On multivariate analysis, second or third <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> was the only independent significant risk factor for development of grade 2\u20104 <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.015). Serial PCR monitoring of urine and blood <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> load did not predict <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. The recent increase in the incidence of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> may reflect recent innovations in transplant technologies that facilitate second or third <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, which are known to cause prolonged immune deficiency. If safe and effective treatment or prophylaxis becomes available, it could be used to target the high\u2010risk patients for <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.13183","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T14:44:17Z","timestamp":1523717057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["High incidence of <scp>BK<\/scp> virus\u2010associated hemorrhagic cystitis in children after second or third allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-2011","authenticated-orcid":false,"given":"Katsutsugu","family":"Umeda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Graduate School of Medicine Kyoto University  Kyoto 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