{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:39:59Z","timestamp":1774899599735,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disease recurrence affects around a third of renal transplants for children with <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> and is associated with poor graft outcomes. Unfortunately, there are no large trials guiding treatment for recurrent <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>. We aimed to describe current therapies and treatment response for recurrent <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> in 4 centres in Australia and New Zealand. Data were collected on children (age &lt;18\u00a0years) with recurrent <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> (1990\u20102015). We reviewed patient charts to obtain clinical information. Ethics approval was obtained from the relevant boards. Complete records were available on 24 patients (62% female, 54% Caucasian). Median time to first recurrence was 4\u00a0days (IQR 2\u20105\u00a0days). There were 14 separate treatment regimens, involving an average of 2 agents. The most common therapies were plasma exchange (20\/24 patients, 83%), cyclosporin (15\/24, 63%), and methylprednisolone (9\/24, 38%). Full remission was achieved in 15 (63%), partial remission in 2 (8%), and no remission in 7 (29%) patients. Of the patients with no remission, 5 lost their graft to recurrent disease and 1 to concurrent acute vascular rejection. The plethora of different treatment regimens reflects the poor evidence guiding management for recurrent <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>. More research is needed to improve outcomes.<\/jats:p>","DOI":"10.1111\/petr.13185","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T01:30:39Z","timestamp":1524187839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Treatment of recurrent focal segmental glomerulosclerosis post\u2010kidney transplantation in Australian and New Zealand children: A retrospective cohort study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5106-3712","authenticated-orcid":false,"given":"Anna","family":"Francis","sequence":"first","affiliation":[{"name":"Child and Adolescent Renal Services Lady Cilento Children's Hospital  South Brisbane Qld Australia"},{"name":"Centre for Kidney Research University of Sydney  Sydney NSW 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