{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:26Z","timestamp":1753879346740,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell\u2010depleted HAPLO <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> is an option to treat children with high\u2010risk acute leukemia lacking an <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010identical donor. We reviewed the outcome of children with acute leukemia after HAPLO (n\u00a0=\u00a021) and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010MUD (n\u00a0=\u00a032) transplantation. The proportion of patients with \u2265CR2 was significantly higher in HAPLO transplantation than <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplantation. Patients with <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplantation were significantly higher <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> incompatible than patients with HAPLO transplantation. There was no difference between the 2 groups in terms of engraftment, aGvHD and cGv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VOD<\/jats:styled-content>, hemorrhagic cystitis, infections, and relapse. The 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplantation and HAPLO transplantation groups was found 65.8% and 71.1%, respectively (log\u2010rank 0.51). The 5\u2010year <jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content> was 80.7% for <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplantation group and 86.9% for HAPLO transplantation group (log\u2010rank 0.48). There was no statistically significant difference between 2 groups according to <jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content> (25% <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplantation vs 16.3% HAPLO transplantation, log\u2010rank 0.48). These data suggest that survival for patients with high\u2010risk acute leukemia after HAPLO transplantation with ex vivo \u0251\u03b2<jats:sup>+<\/jats:sup> T\u2010cell depletion is comparable with <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplantation.<\/jats:p>","DOI":"10.1111\/petr.13192","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T02:30:13Z","timestamp":1523932213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of outcomes after <scp>HLA<\/scp>\u2010matched unrelated and \u03b1\u03b2 T\u2010cell\u2010depleted haploidentical hematopoietic stem cell transplantation for children with high\u2010risk acute leukemia"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-0407","authenticated-orcid":false,"given":"Fatih","family":"Erbey","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology &amp; Bone Marrow Transplantation Unit Ac\u0131badem University School of Medicine, Atakent Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Ak\u00e7ay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology &amp; Bone Marrow Transplantation Unit Ac\u0131badem University School of Medicine, Atakent Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-1959","authenticated-orcid":false,"given":"Didem","family":"Atay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology &amp; Bone Marrow Transplantation Unit Ac\u0131badem University School of Medicine, Atakent Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erc\u00fcment","family":"Oval\u0131","sequence":"additional","affiliation":[{"name":"Department of Hematology Ac\u0131badem University School of Medicine Altunizade Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcly\u00fcz","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology &amp; Bone Marrow Transplantation Unit Ac\u0131badem University School of Medicine, Atakent Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-207001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.34"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.11.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.306"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283582340"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563817"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.08.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1641402"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.87"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.161"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.9747"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-779769"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.92"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.02.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.11.016"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:34:34Z","timestamp":1695494074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/petr.13192"],"URL":"https:\/\/doi.org\/10.1111\/petr.13192","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2018,4,16]]},"assertion":[{"value":"2018-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13192"}}