{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:21:01Z","timestamp":1761920461826,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Ministry of Health, Labor Sciences Research","award":["H23-042","H24-037","H26-045"],"award-info":[{"award-number":["H23-042","H24-037","H26-045"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Severe portopulmonary hypertension (POPH<\/jats:styled-content>) is a contraindication for liver transplantation (LT<\/jats:styled-content>) because of the high risk of postoperative heart failure. The early detection of POPH<\/jats:styled-content> is important for patients with biliary atresia (BA<\/jats:styled-content>). Brain natriuretic peptide (BNP<\/jats:styled-content>) is known to be correlated with liver fibrosis in patients with liver cirrhosis. The aim of this study was to elucidate the efficacy of BNP<\/jats:styled-content> measurement for the follow\u2010up of patients with BA<\/jats:styled-content>. Thirty\u2010two patients with BA<\/jats:styled-content> were identified from September 2011 to December 2016. As indices of liver fibrosis\/cirrhosis, APRI<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001), FIB<\/jats:styled-content>\u20104 (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001), Child\u2010Pugh score (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001), IV<\/jats:styled-content> collagen (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.0005), and hyaluronic acid (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.0291) had high or moderate correlations with BNP<\/jats:styled-content>. Patients with splenomegaly, esophageal varices, liver fibrosis, and collateral veins had significantly higher BNP<\/jats:styled-content> levels than those without. Patients diagnosed with POPH<\/jats:styled-content> had significantly higher BNP<\/jats:styled-content> levels in comparison with those patients without (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.0068). In contrast, PELD<\/jats:styled-content>\/MELD<\/jats:styled-content> scores showed an almost negligible correlation with the BNP<\/jats:styled-content> level. LT<\/jats:styled-content> was successful in 3 asymptomatic BA<\/jats:styled-content> patients with POPH<\/jats:styled-content> who had high BNP<\/jats:styled-content> levels despite the low PELD<\/jats:styled-content>\/MELD<\/jats:styled-content> scores. In conclusion, routine serum BNP<\/jats:styled-content> surveillance can be easy to predict asymptomatic POPH<\/jats:styled-content>. This may help to identify POPH<\/jats:styled-content> before it reaches a stage that would contraindicate LT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.13203","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T14:32:03Z","timestamp":1525703523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The efficacy of serum brain natriuretic peptide for the early detection of portopulmonary hypertension in biliary atresia patients before liver transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8709-7313","authenticated-orcid":false,"given":"Koichiro","family":"Yoshimaru","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Faculty of Medical Sciences Kyushu University Fukuoka 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