{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:41:32Z","timestamp":1780576892740,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> is a practical therapeutic alternative for unresectable hepatoblastoma; however, deciding when to perform <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> is difficult. The aim of this study was to optimize the timing of <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for hepatoblastoma using pretransplant trends in <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> levels. Trends in pretransplant <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> levels and their influence on post\u2010transplant outcomes were retrospectively evaluated. All patients who underwent living donor <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for hepatoblastoma in our institution since 2002 were included. Variables analyzed included history of prior tumor resection, pretransplant <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> responses to chemotherapy, metastatic disease at diagnosis, and post\u2010transplant chemotherapy. Eight patients (seven boys and one girl; median age, 35\u00a0months; range, 15\u00a0months\u201012\u00a0years) were transplanted. The overall post\u2010transplant recurrence\u2010free survival rate was 62.5% (5\/8) with a mean follow\u2010up of 77\u00a0months. Patients with post\u2010transplant recurrence showed a 0.573 log increase in <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> levels after the last chemotherapy session before <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. This was significantly higher than the 0.279 log decrease observed in patients without post\u2010transplant recurrence (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.024). Because the <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> response cannot be accurately predicted before each cycle of chemotherapy, it may be appropriate to perform <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> when <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> levels do not decrease after the last cycle and before they are found to be elevated again.<\/jats:p>","DOI":"10.1111\/petr.13221","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T09:29:29Z","timestamp":1526376569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pretransplant trends in \u03b1\u2010fetoprotein levels as a predictor of recurrence after living donor liver transplantation for unresectable hepatoblastoma: A single\u2010institution experience"],"prefix":"10.1111","volume":"22","author":[{"given":"Kaori","family":"Isono","sequence":"first","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5603-7270","authenticated-orcid":false,"given":"Yuki","family":"Ohya","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang\u2010Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kadohisa","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Sakisaka","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Uto","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Inomata","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Pediatric Surgery Postgraduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(00)00018-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10376"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001936"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90147-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)44469-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20607.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2015.1847"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23803"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01003.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)90454-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.1190"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/088800101753328475"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90762-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.22.3819"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.32886"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2708-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10282"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199102000-00004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90164-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30264"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.09.011"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21586"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.09.017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.08.038"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.10.023"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200209150-00011"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.05.031"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:19:48Z","timestamp":1695043188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/petr.13221"],"URL":"https:\/\/doi.org\/10.1111\/petr.13221","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"assertion":[{"value":"2018-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13221"}}