{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:30:06Z","timestamp":1761514206395,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content> is a fatal X\u2010linked combined immunodeficiency syndrome, the only cures for which are <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> or gene therapy. <jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content> occur in up to 72% of patients with <jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content> who do not receive <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, likely arising secondary to impaired multilineage immune autoregulatory function; <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content> is not typically seen. In this article, we describe the case of a male patient who underwent <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010matched <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content> at the age of 5\u00a0months, with his sister (a <jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content> carrier) acting as his donor and subsequently developed <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content> 12\u00a0months post\u2010transplant, with marked elevation of antithyroid peroxidase antibody titer. His donor sister was subsequently found to have elevated antithyroid peroxidase antibody titer with increasing trend and normal thyroid function.\u00a0Although several mechanisms exist by which our patient may have developed <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>, we suggest the transfer of autoreactive donor immune cells as the most plausible explanation.<\/jats:p>","DOI":"10.1111\/petr.13222","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T09:29:29Z","timestamp":1526376569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autoimmune thyroiditis following <scp>HLA<\/scp>\u2010matched sibling hematopoietic stem cell transplantation for Wiskott\u2010Aldrich syndrome"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7828-1522","authenticated-orcid":false,"given":"Tristan","family":"Knight","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology Oncology Children\u2019s Hospital of Michigan  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Kotz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Children\u2019s Hospital of Michigan  Detroit MI USA"},{"name":"Pediatric Blood and Marrow Transplantation Program Children\u2019s Hospital of Michigan  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcreyya","family":"Sava\u015fan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Children\u2019s Hospital of Michigan  Detroit MI USA"},{"name":"Pediatric Blood and Marrow Transplantation Program Children\u2019s Hospital of Michigan  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Online Mendelian Inheritance in Man OMIM [Internet].Johns Hopkins University Baltimore MD. 300392;WAS GENE; WAS. 2018 Jan 16. 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