{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:10:01Z","timestamp":1775833801396,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","award":["Research and Development Grant (00539)"],"award-info":[{"award-number":["Research and Development Grant (00539)"]}],"id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Assignment of CMV infection status in infants awaiting SOT is challenging as passive maternal antibody can lead to false\u2010positive serology. Since 2000, our protocol has recommended sending throat and urine samples for CMV viral detection, culture, or NAAT, for CMV\u2010seropositive infants &lt;18\u00a0months awaiting SOT. We reviewed pretransplant CMV serology for 152 infants and, for CMV seropositives, examined relationships between CMV IgG OD values, age, and CMV viral detection to explore time to clearance of maternal CMV IgG and evaluate viral detection in assignment of pretransplant CMV infection status. The proportion of CMV\u2010seropositive infants decreased from 52% in infants 0\u20106\u00a0months of age to 28% in those 12\u201018\u00a0months. Among CMV\u2010seropositive infants, median OD was significantly higher in the 6\u2010 to 12\u2010 and 12\u2010 to 18\u2010month groups compared to the 0\u2010 to 6\u2010month group. Distribution of OD by age group suggested that maternal antibody cleared before 12\u00a0months. Of 59 eligible CMV\u2010seropositive infants, 49 (83%) had CMV viral detection studies and 18 of 49 (36.7%) had detectable CMV: 9 of 30 (30.0%) infants 0\u20106\u00a0months, 7 of 15 (46.7%) infants 6\u201012\u00a0months, and 2 of 4 (50.0%) infants 12\u201018\u00a0months. CMV viral detection studies are useful to confirm positive CMV infection status in CMV\u2010seropositive infants awaiting SOT. Maternal CMV IgG likely clears before 12\u00a0months.<\/jats:p>","DOI":"10.1111\/petr.13229","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T05:20:27Z","timestamp":1527225627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assignment of cytomegalovirus infection status in infants awaiting solid organ transplant: Viral detection methods as adjuncts to serology"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-5582","authenticated-orcid":false,"given":"Catherine E.","family":"Burton","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Dragan","sequence":"additional","affiliation":[{"name":"DynaLife Medical Labs  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis A.","family":"Mabilangan","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila F.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Ottawa ON Canada"},{"name":"School of Epidemiology, Public Health and Preventive Medicine University of Ottawa  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Fearon","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Toronto ON Canada"},{"name":"Department of Pathology &amp; Laboratory Medicine University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Scalia","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta K.","family":"Preiksaitis","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/10898540-000000000-00000"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829df29d"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6284"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-304"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.1999.01118.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80006-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.242.513"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400044983"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00697-14"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/652438"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv193"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2006.21.1.5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/CDLI.6.6.868-871.1999","article-title":"Decay of passively acquired maternal antibodies against measles, mumps, and rubella viruses","volume":"6","author":"Nicoara C","year":"1999","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.695"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.3.746-752.2002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/314939"},{"key":"e_1_2_8_20_1","first-page":"137","article-title":"Role of cytomegalovirus IgG avidity testing in diagnosing primary CMV infection during pregnancy","volume":"2","author":"Prince H","year":"2014","journal-title":"Clin Vaccine Immunol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-014-0568-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-014-0569-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu627"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:20:02Z","timestamp":1695043202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,24]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/petr.13229"],"URL":"https:\/\/doi.org\/10.1111\/petr.13229","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,24]]},"assertion":[{"value":"2018-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13229"}}