{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:03Z","timestamp":1753879263615,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatic SOS is a potentially life\u2010threatening complication of conditioning for allogeneic HSCT. rTM is a new drug for treating DIC. We report our experience of the use of <jats:styled-content style=\"fixed-case\">rTM<\/jats:styled-content> as a prophylaxis against <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> in high\u2010risk pediatric patients that underwent <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. We evaluated the cases of 19 pediatric hematology and oncology patients who underwent <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> at our institution between 2007 and 2016. The patients who received <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> after 2012 (n\u00a0=\u00a08) were treated with <jats:styled-content style=\"fixed-case\">rTM<\/jats:styled-content> as a prophylaxis against <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> together with UDCA and LMWH, whereas the others (n\u00a0=\u00a011) were only treated with <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LMWH<\/jats:styled-content>. Although <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> occurred by post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> day 35 in 3 (27%) patients in the control group, <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> was not seen in the <jats:styled-content style=\"fixed-case\">rTM<\/jats:styled-content> group. Two of the former three patients suffered severe <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>, and one died of the condition. The mean peak level of PAI\u20101 (a marker of endothelial damage) was significantly lower in the <jats:styled-content style=\"fixed-case\">rTM<\/jats:styled-content> group. <jats:styled-content style=\"fixed-case\">rTM<\/jats:styled-content> appears to be a safe prophylaxis for <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>. The present findings suggest that prophylactic <jats:styled-content style=\"fixed-case\">rTM<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> might help to prevent SOS.<\/jats:p>","DOI":"10.1111\/petr.13269","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T01:15:17Z","timestamp":1531444517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prophylactic recombinant thrombomodulin treatment prevents hepatic sinusoidal obstruction syndrome in high\u2010risk pediatric patients that undergo hematopoietic stem cell transplants"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-7062","authenticated-orcid":false,"given":"Shohei","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics Showa University Fujigaoka Hospital  Yokohama 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