{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:20:48Z","timestamp":1790774448993,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We report a case series of histoplasmosis in <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x patients in a children's hospital in an endemic area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x cases from January 1, 2002, to August 31, 2016, were reviewed to identify those with disseminated histoplasmosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The attack rate of histoplasmosis among our <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x patients was 6.9 per 100 cases. The median age at the time of diagnosis was 16\u00a0years (11\u201018). Comorbidities included glomerulosclerosis (3), medullary cystic disease (1), and obstructive uropathy (2) and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> (1). There were 5 deceased and 1 living\u2010related donor transplants, and no patient had a history of rejection prior to histoplasmosis. Median time from transplant to histoplasmosis was 14.8\u00a0months (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 2.2\u201038.3) and 33% occurred in the first year after transplant. Urine and\/or serum antigens were positive in all patients. They were either treated with amphotericin B and transitioned to an azole or received azole monotherapy. Most (83%) received chronic suppression with itraconazole. No patients died and relapse occurred in 1 patient after repeat transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x patients in endemic areas are at risk for disseminated histoplasmosis. Further study is needed to determine which factors portend the need for fungal prophylaxis in this subset of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13274","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T06:17:36Z","timestamp":1533622656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Disseminated histoplasmosis in pediatric kidney transplant recipients\u2014A report of six cases and review of the literature"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-1686","authenticated-orcid":false,"given":"Kenice","family":"Ferguson\u2010Paul","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of General Pediatrics Le Bonheur Children's Hospital University of Tennessee Health Sciences Center  Memphis Tennessee"},{"name":"Department of Pediatrics Division of General Pediatrics University of Tennessee Health Sciences Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of General Pediatrics University of Tennessee Health Sciences Center  Memphis Tennessee"},{"name":"Department of Pediatrics Division of Nephrology Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Childress","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Nephrology University of Tennessee Health Sciences Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of General Pediatrics Le Bonheur Children's Hospital University of Tennessee Health Sciences Center  Memphis Tennessee"},{"name":"Department of Pediatrics Division of Infectious Diseases University of Tennessee Health Sciences Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Ault","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Nephrology University of Tennessee Health Sciences Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindiya","family":"Bagga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of General Pediatrics Le Bonheur Children's Hospital University of Tennessee Health Sciences Center  Memphis Tennessee"},{"name":"Department of Pediatrics Division of Infectious Diseases University of Tennessee Health Sciences Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Principles, Practices of Diseases Pediatric Infectious","author":"Long S","year":"2012"},{"key":"e_1_2_6_3_1","unstructured":"HageCA PescovitzL WheatJ.Histoplasmosis in Solid Organ Transplant Patients.http:\/\/www.antimicrobe.org. Accessed August 25 2017."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328306eb8d"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(79)90050-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8365.2005.00105.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1983.00350040093012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit593"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03493.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/604712"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1397-3142.2003.00103.x"},{"key":"e_1_2_6_13_1","unstructured":"Janssen Pharmaceuticals I.SPORANOX\u00ae (itraconazole) prescribing information.http:\/\/www.janssenpharmaceuticalsinc.com\/assets\/sporanox.pdf. Accessed June 13 2018."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.12.1730"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.10.056"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2005.06.005"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:13:05Z","timestamp":1694823185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,3]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/petr.13274"],"URL":"https:\/\/doi.org\/10.1111\/petr.13274","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,3]]},"assertion":[{"value":"2018-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13274"}}