{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:33:39Z","timestamp":1791232419978,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>KT recipients have increased the risk of CVD. The incidence of post\u2010transplant CVEs among pediatric recipients has not been well\u2010characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Between 1963 and 2015, 884 pediatric (age: 0\u201017\u00a0years old) recipients received 1058 KTs at our institution. The cumulative incidence of CVEs was analyzed. Statistical models were used to estimate risk factors for developing post\u2010transplant CVEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall median patient survival was 33\u00a0years (IQR: 18.7\u201047). A total of 362 CVEs occurred in 161 (18.3%) patients at a median age of 20.5\u00a0years. Arrhythmias (18%) were most common. Cumulative risk of post\u2010transplant CVEs was 9% at 10\u00a0years, 17% at 20\u00a0years, 25% at 30\u00a0years, and 36% at 40\u00a0years. Development of post\u2010transplant CVEs was associated with increased mortality (HR 2.25 [95% CI 1.61\u20103.14]); of those who developed a CVE and died, 22\/51 (43.1%) died of CVD. Multivariable risk factors for post\u2010transplant CVEs included a history of pretransplant CVD (aHR 1.92 [1.18\u20103.13] and graft failure (4.57 [3.13\u20106.67]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>A pretransplant history of CVD and a failed graft are significant risk factors for the development of post\u2010transplant CVE. CVD increases the risk of post\u2010transplant death or graft loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13283","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T21:06:23Z","timestamp":1535576783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Incidence and magnitude of post\u2010transplant cardiovascular disease after pediatric kidney transplantation: Risk factor analysis of 1058 pediatric kidney transplants at the university of Minnesota"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5076-0938","authenticated-orcid":false,"given":"Oscar K.","family":"Serrano","sequence":"first","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananta 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