{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:27:23Z","timestamp":1761017243865,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>RV<\/jats:styled-content> systolic function is important early after HT<\/jats:styled-content>; however, it has not been critically assessed in children using quantitative measures. The aim of this study was to describe the most validated and commonly used quantitative echocardiographic measures of RV<\/jats:styled-content> systolic function early after pediatric HT<\/jats:styled-content> and to assess associations with qualitative function evaluation and clinical factors. RV<\/jats:styled-content> systolic function was quantified on the first post\u2010HT<\/jats:styled-content> echocardiogram >24\u00a0hours after cardiopulmonary bypass using two\u2010dimensional TAPSE<\/jats:styled-content>, Tricuspid annular S\u2019, FAC<\/jats:styled-content>, and MPI<\/jats:styled-content>. In 145 patients (median age 7.6\u00a0years), quantitative RV<\/jats:styled-content> systolic function was markedly abnormal: mean TAPSE <\/jats:styled-content>z<\/jats:italic>\u2010score \u22128.43\u00a0\u00b1\u00a01.89; S\u2019 z<\/jats:italic>\u2010score \u22124.36\u00a0\u00b1\u00a01.22; FAC<\/jats:styled-content> 24.4\u00a0\u00b1\u00a08.34%; and MPI<\/jats:styled-content> 0.86\u00a0\u00b1\u00a00.51. Few patients had normal quantitative function: TAPSE<\/jats:styled-content> (0%), S\u2019 (1.2%), FAC<\/jats:styled-content> (9.4%), and MPI<\/jats:styled-content> (28.4%). In contrast, 48.3% were observed as normal by qualitative assessment. Most clinical factors, including diagnosis, pulmonary vascular resistance, posttransplant hemodynamics, inotropic support, and rejection, were not associated with RV<\/jats:styled-content> function. In this large pediatric HT<\/jats:styled-content> population, TAPSE<\/jats:styled-content>, S\u2019, FAC<\/jats:styled-content>, and MPI<\/jats:styled-content> were strikingly abnormal early post\u2010HT<\/jats:styled-content> despite reassuring qualitative assessment and no significant association with clinical factors. This suggests that the accepted normal values of these quantitative measures may not apply in the early post\u2010HT<\/jats:styled-content> period to accurately grade RV<\/jats:styled-content> systolic function, and there may be utility in adapting a concept of normal reference values after pediatric HT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13286","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T01:44:24Z","timestamp":1536025464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early assessment of right ventricular systolic function after pediatric heart transplant"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-4712","authenticated-orcid":false,"given":"Jamie K.","family":"Harrington","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics College of 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