{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:22:49Z","timestamp":1787505769603,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1512553"],"award-info":[{"award-number":["1512553"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE\u20101311230"],"award-info":[{"award-number":["DGE\u20101311230"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Listed pediatric heart transplant patients have the highest solid\u2010organ waitlist mortality rate. The donor\u2010recipient body weight (\n                      <jats:styled-content style=\"fixed-case\">DRBW<\/jats:styled-content>\n                      ) ratio is the clinical standard for allograft size matching but may unnecessarily limit a patient's donor pool. To overcome\n                      <jats:styled-content style=\"fixed-case\">DRBW<\/jats:styled-content>\n                      ratio limitations, two methods of performing virtual heart transplant fit assessments were developed that account for patient\u2010specific nuances. Method 1 uses an allograft total cardiac volume (\n                      <jats:styled-content style=\"fixed-case\">TCV<\/jats:styled-content>\n                      ) prediction model informed by patient data wherein a matched allograft 3\u2010D reconstruction is selected from a virtual library for assessment. Method 2 uses donor images for a direct virtual transplant assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Assessments were performed in medical image reconstruction software. The allograft model was developed using allometric\/isometric scaling assumptions and cross\u2010validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final predictive model included gender, height, and weight. The 25th\u2010, 50th\u2010, and 75th\u2010percentiles for\n                      <jats:styled-content style=\"fixed-case\">TCV<\/jats:styled-content>\n                      percentage errors were \u221213% (over\u2010prediction), \u22121%, and 8% (under\u2010prediction), respectively. Two examples illustrating the potential of virtual assessments are presented.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transplant centers can apply these methods to perform their virtual assessments using existing technology. These techniques have potential to improve organ allocation. With additional experience and refinement, virtual transplants may become standard of care for determining suitability of donor organ size for an identified recipient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.13290","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T23:39:25Z","timestamp":1537832365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Alternative methods for virtual heart transplant\u2014Size matching for pediatric heart transplantation with and without donor medical images available"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-2259","authenticated-orcid":false,"given":"Jonathan D.","family":"Plasencia","sequence":"first","affiliation":[{"name":"School of Biological and Health Systems Engineering Arizona State University  Tempe Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis","family":"Kamarianakis","sequence":"additional","affiliation":[{"name":"School of Mathematical and Statistical Sciences Arizona State University  Tempe Arizona"},{"name":"Institute of Applied and Computational Mathematics Foundation for Research and Technology \u2010 Hellas  Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Cardiology Division of Cardiothoracic Surgery Children's Heart Center Phoenix Children's Hospital  Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Karamlou","sequence":"additional","affiliation":[{"name":"Mayo Clinic Hospital  Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Division of Cardiothoracic Surgery Children's Heart Center Phoenix Children's Hospital  Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Nigro","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Rady Children's Hospital  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David. 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