{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:44:13Z","timestamp":1793148253490,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>pLT is a highly standardized therapy for children with end\u2010stage liver disease and liver\u2010based metabolic diseases. However, NCs after transplantation occur and especially younger children are considered as more vulnerable and susceptible to NCs. Up to now, detailed data particularly for the very young age group do not exist. We therefore retrospectively studied NCs in children after pLT under age of 24\u00a0months. Forty children aged between 19\u00a0days and 22\u00a0months were evaluated according to type of NC and potential risk factors. NCs occurred in 8\/40 patients (20%). All experienced new\u2010onset seizures and in 1\/6 surviving patients, seizures evolved into epilepsy. Other NCs were intracerebral abscess (1\/8 patients) and subdural hemorrhage (1\/8 patients). The overall 3\u2010year mortality rate was 10% (4\/40 patients). Significant risk factors for NCs and therefore seizures were HAT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.020), total surgery time (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009), retransplantation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), period of catecholamine therapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.024), period of mechanical ventilation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.014), and period of sedation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.010). Our study is the first to provide detailed information on NCs after pLT in children under 24\u00a0months of age. The incidence of NCs in this particular group of very young patients was not increased compared to previously published data of children of all ages. Main NC was new\u2010onset seizure. In the surviving infants, prognosis of seizure was excellent and the risk of developing epilepsy was low. Even more, the occurrence of NCs did not significantly affect mortality or survival in this particular age group.<\/jats:p>","DOI":"10.1111\/petr.13304","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T05:23:13Z","timestamp":1539408193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Liver transplantation during infancy: No increased rate of neurological complications"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5053-5618","authenticated-orcid":false,"given":"Markus","family":"Ameres","sequence":"first","affiliation":[{"name":"KUNO University Children\u2019s Hospital Regensburg Bavaria Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-0758","authenticated-orcid":false,"given":"Michael","family":"Melter","sequence":"additional","affiliation":[{"name":"KUNO University 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