{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:19:43Z","timestamp":1791937183101,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Improvement in outcomes of LT for pediatric HB and HCC has been reported in small series. We analyzed national outcomes and changes in donor, recipient, and perioperative factors over time that may contribute to survival differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The UNOS database was queried for patients age &lt;21\u00a0years that underwent LT for a primary diagnosis of HB or HCC (1987\u20102017). Subjects were divided into historic (transplant before 2010) and contemporary (transplant after 2010) cohorts. Baseline characteristics were compiled and examined. Survival was estimated using the Kaplan\u2010Meier method and compared using the log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 599 children with HB received LT (320 historic vs 279 contemporary). Concurrently, 141 children with HCC received LT (92 historic vs 49 contemporary). For both tumors, waitlist time decreased (HB 56.2\u00a0days historic vs 33.2\u00a0days contemporary, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017; HCC 189.3\u00a0days historic vs 71.7\u00a0days contemporary, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). In the historic cohorts, patients with HB had a 1\u2010year and 5\u2010year OS of 84.6% and 75.1%, respectively. Survival for HCC was 84.4% and 59.9%, respectively. Outcomes improved in the contemporary era to 89.1% and 82.6% for HB, and 94.7% and 80.8% for HCC, respectively (both log\u2010rank test <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcomes of LT have improved significantly, with contemporary survival now equivalent between these tumors and exceeding 80% 5\u2010year OS. Future studies are needed to explore whether offering LT in patients that are resectable is justifiable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13305","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T02:27:52Z","timestamp":1540002472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Improved contemporary outcomes of liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-0185","authenticated-orcid":false,"given":"Brian","family":"Ezekian","sequence":"first","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Mulvihill","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Schroder","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian F.","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold J.","family":"Leraas","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Gulack","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Jane Commander","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha M.","family":"Mavis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan G.","family":"Kreissman","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Pediatrics Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Knechtle","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth T.","family":"Tracy","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Barbas","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:3<396::AID-CNCR2820200308>3.0.CO;2-O"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23295"},{"key":"e_1_2_9_4_1","unstructured":"COG AHEP\u20100731 treatment protocol: treatment of children with all stages of hepatoblastoma.https:\/\/www.childrensoncologygroup.org\/. 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