{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:26:03Z","timestamp":1768436763480,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The hybrid stage 1 palliation for hypoplastic left heart syndrome (HLHS) was first described in 1993 as a bridge to heart transplant for HLHS. There are limited data on this strategy as primary heart transplantation for HLHS has become less common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is an observational, single\u2010center study comparing pre\u2010 and post\u2010transplant outcomes of patients listed for transplant following hybrid palliation with those following surgical stage 1 palliation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2004 to 2017, 21 patients underwent hybrid palliation as a bridge to heart transplant and 28 patients were listed for transplant following surgical stage 1 palliation or aortic arch repair and pulmonary artery band placement. Premature birth and the presence of genetic or anatomic abnormalities were more common in the hybrid group. Need for extracorporeal membrane oxygenation (ECMO) support and ventricular dysfunction was more common in the surgical group. There was a trend toward shorter waitlist times in the surgical cohort (36\u00a0days vs 70\u00a0days, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). There was no difference in waitlist mortality (19% vs 21%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.61). Survival at 1 and 5\u00a0years post\u2010transplant was similar for the hybrid and surgical cohorts (5\u2010year survival, 80% vs 85%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.94, respectively). There was no difference in the number of post\u2010transplant interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the hybrid patients represented a higher risk cohort and demonstrated longer wait times, the waitlist and post\u2010transplant mortality was equivalent between the two groups. For high\u2010risk patients, the hybrid palliation as a bridge to transplant appears to be a reasonable strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13307","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T07:11:28Z","timestamp":1539933088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hybrid stage 1 palliation as a bridge to cardiac transplantation in patients with high\u2010risk single ventricle physiology"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-7518","authenticated-orcid":false,"given":"Brian H.","family":"Morray","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-4195","authenticated-orcid":false,"given":"Erin L.","family":"Albers","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas K.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9484-3006","authenticated-orcid":false,"given":"Mariska S.","family":"Kemna","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester C.","family":"Permut","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuk M.","family":"Law","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198610093151507"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(96)00295-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00855-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340311797484231"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.01.019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.815712"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.69.6.551"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282205"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.6.645"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-004-0962-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-1015-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.05.021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.04.061"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912461"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.12.013"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs326"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu547"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.033"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.032"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.06.005"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:57:06Z","timestamp":1694757426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,19]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/petr.13307"],"URL":"https:\/\/doi.org\/10.1111\/petr.13307","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,19]]},"assertion":[{"value":"2018-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13307"}}