{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:19:35Z","timestamp":1767849575472,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary hyperoxalurias are rare inborn errors of metabolism with deficiency of hepatic enzymes that lead to excessive urinary oxalate excretion and overproduction of oxalate which is deposited in various organs. Hyperoxaluria results in serious morbid\u2010ity, end stage kidney disease (ESKD), and mortality if left untreated. Combined liver kidney transplantation (CLKT) is recognized as a management of ESKD for children with hyperoxaluria type 1 (PH1). This study aimed to report outcome of CLKT in a pediatric cohort of PH1 patients, through retrospective analysis of data of 8 children (2 girls and 6 boys) who presented by PH1 to Wadi El Nil Pediatric Living Related Liver Transplant Unit during 2001\u20102017. Mean age at transplant was 8.2\u00a0\u00b1\u00a04\u00a0years. Only three of the children underwent confirmatory genotyping. Three patients died prior to surgery on waiting list. The first attempt at CLKT was consecutive, and despite initial successful liver transplant, the girl died of biliary peritonitis prior to scheduled renal transplant. Of the four who underwent simultaneous CLKT, only two survived and are well, one with insignificant complications, and other suffered from abdominal Burkitt lymphoma managed by excision and resection anastomosis, four cycles of rituximab, cyclophosphamide, vincristine, and prednisone. The other two died, one due to uncontrollable bleeding within 36\u00a0hours of procedure, while the other died awaiting renal transplant after loss of renal graft to recurrent renal oxalosis 6\u00a0months post\u2010transplant. PH1 with ESKD is a rare disease; simultaneous CLKT offers good quality of life for afflicted children. Graft shortage and renal graft loss to oxalosis challenge the outcome.<\/jats:p>","DOI":"10.1111\/petr.13313","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T15:45:51Z","timestamp":1543247151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Combined liver\u2010kidney transplantation for primary hyperoxaluria type I in children: Single Center Experience"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5928-8684","authenticated-orcid":false,"given":"Magd A.","family":"Kotb","sequence":"first","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"},{"name":"Wadi El Nil Hospital Pediatric Living\u2010Related Liver Transplantation Team  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa F.","family":"Hamza","sequence":"additional","affiliation":[{"name":"Wadi El Nil Hospital Pediatric Living\u2010Related Liver Transplantation Team  Cairo Egypt"},{"name":"Faculty of Medicine, Department of Pediatric Surgery Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"Abd El Kader","sequence":"additional","affiliation":[{"name":"Wadi El Nil Hospital Pediatric Living\u2010Related Liver Transplantation Team  Cairo Egypt"},{"name":"Faculty of Medicine, Department of Pediatric Surgery Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"El Monayeri","sequence":"additional","affiliation":[{"name":"Wadi El Nil Hospital Pediatric Living\u2010Related Liver Transplantation Team  Cairo Egypt"},{"name":"Faculty of Medicine, Department of Pathology Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia S.","family":"Mosallam","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazira","family":"Ali","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"},{"name":"Wadi El Nil Hospital Pediatric Living\u2010Related Liver Transplantation Team  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine William Shaker","family":"Basanti","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafez","family":"Bazaraa","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"},{"name":"Department of Pediatrics, Center of Pediatric Nephrology &amp; Transplantation, Kasr Al Ainy School of Medicine Cairo University Cairo Egypt"},{"name":"Egyptian Group for Orphan Renal Diseases (EGORD) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Pediatric Oncology, National Cancer Institute Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa M.","family":"Nabhan","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"},{"name":"Department of Pediatrics, Center of Pediatric Nephrology &amp; Transplantation, Kasr Al Ainy School of Medicine Cairo University Cairo Egypt"},{"name":"Egyptian Group for Orphan Renal Diseases (EGORD) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hend","family":"Abd El Baky","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"},{"name":"Wadi El Nil Hospital Pediatric Living\u2010Related Liver Transplantation Team  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally T. Mostafa","family":"El Sorogy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Public Mounira Hospital Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inas E.M.","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Research Center Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda","family":"Ismail","sequence":"additional","affiliation":[{"name":"Wadi El Nil Hospital Pediatric Living\u2010Related Liver Transplantation Team  Cairo Egypt"},{"name":"Department of Pediatrics Wadi El Nil Hospital Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"},{"name":"Department of Pediatrics, Center of Pediatric Nephrology &amp; Transplantation, Kasr Al Ainy School of Medicine Cairo University Cairo Egypt"},{"name":"Egyptian Group for Orphan Renal Diseases (EGORD) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safaa M.","family":"Abd El Rahman","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"},{"name":"Department of Pediatrics, Center of Pediatric Nephrology &amp; Transplantation, Kasr Al Ainy School of Medicine Cairo University Cairo Egypt"},{"name":"Pediatric Oncology, National Cancer Institute Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neveen A.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics Cairo University Cairo Egypt"},{"name":"Department of Pediatrics, Center of Pediatric Nephrology &amp; Transplantation, Kasr Al Ainy School of Medicine Cairo University Cairo Egypt"},{"name":"Egyptian Group for Orphan Renal Diseases (EGORD) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nephro.2016.08.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14418"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v4.i2.235"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00488.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2015.107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06820613"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1867-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a27939"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.41803"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3880-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086359"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs078"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2444-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-017-0996-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/10.supp8.14"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3782-5"},{"issue":"3","key":"e_1_2_10_18_1","first-page":"126","article-title":"Liver\u2010kidney transplantation in primary hyperoxaluria type\u20101: case report and literature review","volume":"2","author":"Siegal D","year":"2011","journal-title":"Int J Organ Transplant Med"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1307-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1085-4"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2012.09.005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0966-3274(94)90080-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03271.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3324-6"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07430711"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.350"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12706"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446382"},{"key":"e_1_2_10_29_1","unstructured":"Act number 5 of year 2010 and Act number 142 of year 2017 for Regulation of Human Organ Donation. 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