{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:11:57Z","timestamp":1774469517040,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>ABO\u2010i heart transplantation can be performed in infants with end\u2010stage heart failure to increase organ availability. The development of newly detected DSAs is associated with decreased cardiac graft survival, and the effect of ABO\u2010i transplantation on DSA production is unknown. We examined DSA production and rejection frequency in infant recipients of ABO\u2010i and ABO\u2010c heart transplants via a retrospective cohort study of infant heart transplant recipients transplanted at a single pediatric center between January 2004 and November 2014. Patients were included if they were less than 1\u00a0year of age at transplant and had a minimum of 6\u00a0months follow\u2010up. DSA positivity was examined under two categories, either the lowest level detectable (MFI\u00a0&gt;\u00a0500) or a level presumed to have clinical relevance in our immunogenetics laboratory (MFI &gt; 5000). Of 52 patients, 36 received ABO\u2010c transplants and 16 received ABO\u2010i transplants. Compared to ABO\u2010c recipients, the ABO\u2010i group showed a consistent but statistically non\u2010significant finding of less frequent ndDSA positivity (69.4% ABO\u2010c vs 43.8% ABO\u2010i with MFI &gt;500, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.122; 41.7% ABO\u2010c vs 25% ABO\u2010i with MFI &gt;5000, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.353). Additionally, ABO\u2010i patients were less likely to have any form of rejection (12.5% vs 47.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.027) or acute cellular rejection (6.3% vs 38.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). Our data suggest that infants receiving ABO\u2010i heart transplants may be less likely to develop ndDSAs or have rejection compared to same age ABO\u2010c recipients. Larger multicenter studies are needed to confirm results from this single center study.<\/jats:p>","DOI":"10.1111\/petr.13332","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T01:53:43Z","timestamp":1543974823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Donor\u2010specific anti\u2010HLA antibody production following pediatric ABO\u2010incompatible heart transplantation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-9633","authenticated-orcid":false,"given":"Chiu\u2010Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Stanford University School of Medicine  Palo Alto California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Warner","sequence":"additional","affiliation":[{"name":"Immunogenetics\/HLA Laboratory Bloodworks Northwest Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin L.","family":"Albers","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children\u2019s Hospital Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariska S.","family":"Kemna","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children\u2019s Hospital Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Delaney","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine Division Children\u2019s National Health System Washington D.C."},{"name":"Departments of Pathology and Pediatrics George Washington University Washington D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borah J.","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle 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