{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:29:06Z","timestamp":1760866146477,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gallbladder agenesis (GA) is a rare congenital condition, occurring in approximately 40\/100.000. It is likely due to an embryologic mishap in the development of the gallbladder bud and can be associated with other congenital variations in biliary anatomy. However, the liver likely suffers no functional impairment and can be safely used for transplantation. To the best of our knowledge, this is the first case report describing a pediatric liver transplantation (PLT) using a graft with GA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 10\u2010year\u2010old boy with methylmalonic aciduria underwent isolated liver transplant with a deceased graft from a donor with no relevant medical or surgical history and normal laboratory tests. During the back\u2010table liver preparation procedure, no evidence of gallbladder was found, raising the possibility of a GA, confirmed by intraoperative cholangiography. The liver transplantation procedure was uneventful despite the particularly rare combination of biliary tree anatomic distribution found in the cholangiography. At 1\u00a0year of follow\u2010up, there were no clinical, laboratory, or imagological signs of bile leaks or anastomotic site stricture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The present report highlights the importance of the accurate knowledge of the vasculobiliary anatomic variation, particularly in extremely rare cases, such as GA, and in complex hepatobiliary procedures, such as PLT. In our opinion, grafts with GA should not be discarded for transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13342","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T16:52:25Z","timestamp":1545411145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful liver transplantation using a whole liver graft with gallbladder agenesis: First report in pediatric liver transplantation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-4736","authenticated-orcid":false,"given":"In\u00eas","family":"Pessanha","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery, Paediatric Hospital Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Alexandrino","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Centro Hospitalar e Universit\u00e1rio de Coimbra University Hospitals of Coimbra Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Piedade","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Paediatric Hospital Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"},{"name":"Paediatric and Adult Liver Transplantation Unit Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Paediatric Hospital Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"},{"name":"Paediatric and Adult Liver Transplantation Unit Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Paediatric and Adult Liver Transplantation Unit Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Francelina","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Paediatric Hospital Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra Coimbra Portugal"},{"name":"Paediatric and Adult Liver Transplantation Unit Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel","family":"Furtado","sequence":"additional","affiliation":[{"name":"Paediatric and Adult Liver Transplantation Unit Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588414X13946184903766"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsurg.2012.07.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2008.07.001"},{"issue":"5","key":"e_1_2_7_5_1","first-page":"767","article-title":"An unusual triad: gall bladder agenesis, annular pancreas and portal anomaly","volume":"46","author":"Martinoli S","year":"1980","journal-title":"Helv Chir Acta"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199304000-00014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i39.6228"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.10.2011.5053"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50129"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-013-1157-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2003.4.2.85"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000102934.93029.89"},{"issue":"4","key":"e_1_2_7_13_1","first-page":"517","article-title":"Agenesis of the gallbladder: lessons to learn","volume":"10","author":"Balakrishnan S","year":"2006","journal-title":"JSLS"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.07.014"},{"key":"e_1_2_7_15_1","article-title":"Resistance index of hepatic artery can predict anastomotic biliary complications after liver transplantation in children","author":"Liao FM","year":"2018","journal-title":"J Formos Med Assoc"},{"issue":"6","key":"e_1_2_7_16_1","first-page":"354","article-title":"Variations of the right bile ducts. 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