{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:23Z","timestamp":1753879343330,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570592"],"award-info":[{"award-number":["81570592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["17JCYBJC27500"],"award-info":[{"award-number":["17JCYBJC27500"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Th17 and imbalance of Treg\/Th17 might be one of the mechanisms of acute rejection. We aim to explore the role of Th17s in the balance of Treg\/Th17 in acute rejection after LT in children diagnosed with BA. The ratios of Treg and Th17 in peripheral blood were detected by flow cytometry pre\u2010LT, post\u2010LT, and when rejection occurred. Treg proportion was higher before transplantation than at 2\u00a0weeks and 1\u00a0month after transplantation, with no statistical difference between 2\u00a0weeks and 1\u00a0month. However, Treg proportions were lower in pediatric recipients than healthy controls. The proportion of Tregs before anti\u2010rejection treatment was lower than control group, with no statistical difference compared to the stable group and it showed no difference compared with that at 2\u00a0weeks and 1\u00a0month post\u2010LT. The Th17 proportions were higher at 2\u00a0weeks and 1\u00a0month after transplantation than healthy controls. The Th17 proportion under the circumstances of rejection was higher than that in the stable group and control group; the proportion in stable group was higher than that in control group. After anti\u2010rejection therapy, the proportions of Th17 were lower than those before therapy. In conclusion, the imbalance of Treg\/Th17, especially Th17s instead of Tregs, may be one of the important mechanisms in acute rejection.<\/jats:p>","DOI":"10.1111\/petr.13363","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T08:21:09Z","timestamp":1550046069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The T\u2010helper cells 17 instead of Tregs play the key role in acute rejection after pediatric liver transplantation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-2913","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery Tianjin First Center Hospital Tianjin China"},{"name":"Tianjin Key Laboratory for Organ Transplantation Tianjin China"},{"name":"Tianjin Clinical Research Center for Organ Transplantation Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-3950","authenticated-orcid":false,"given":"Zhuo\u2010Lun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Tianjin First Center Hospital Tianjin China"},{"name":"Tianjin Key Laboratory for Organ Transplantation Tianjin China"},{"name":"Tianjin Clinical Research Center for Organ Transplantation Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Tianjin First Center Hospital Tianjin China"},{"name":"Tianjin Key Laboratory for Organ Transplantation Tianjin China"},{"name":"Tianjin Clinical Research Center for Organ Transplantation Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Lei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Tianjin First Center Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8800-9840","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Blood Transfusion Department Tianjin First Center Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Tianjin First Center Hospital Tianjin China"},{"name":"Tianjin Key Laboratory for Organ Transplantation Tianjin China"},{"name":"Tianjin Clinical Research Center for Organ Transplantation Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1001\/jama.2011.2014"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1097\/TP.0000000000000666"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/j.intimp.2011.02.010"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1371\/journal.pone.0112135"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1111\/ajt.13617"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1007\/s00281-011-0257-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.4049\/jimmunol.181.6.3906"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1097\/MOT.0b013e32833b9bfb"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1073\/pnas.0708426104"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.4049\/jimmunol.178.11.6725"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1074\/jbc.M801286200"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1097\/MOT.0b013e32833b7929"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1371\/journal.pone.0136214"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1002\/hep.24807"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1007\/s00383-013-3421-6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1016\/j.intimp.2009.01.029"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1016\/j.cyto.2008.03.006"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1016\/j.transproceed.2011.11.026"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T19:55:20Z","timestamp":1694289320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/petr.13363"],"URL":"https:\/\/doi.org\/10.1111\/petr.13363","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2019,2,12]]},"assertion":[{"value":"2018-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13363"}}