{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:14Z","timestamp":1753879274102,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to compare the early results of i.v. with p.o. TAC as a primary immunosuppressant in pediatric patients undergoing LT. This retrospective study enrolled 75 children who underwent LT and received TAC\u2010steroid regimens as a primary immunosuppressant between September 2011 and October 2015 at our institution. Thirty\u2010five recipients received TAC i.v. and 40 received TAC p.o. Early results were evaluated and compared, including ACR, EBV, or CMV infection; renal adverse effects; and hospital stay. Comparisons of 90\u2010day post\u2010transplant results showed that the rates of overall viral (74% vs 40% <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.002), EBV (46% vs 17.5% <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.008), and CMV (51% vs 30% <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) infections were significantly higher in the i.v. than in the p.o. group. Neither regimen has any adverse effects on renal function. There were no between\u2010group differences in ACR incidence and severity, serum creatinine concentration, and hospital stay. Patient and graft survival rates at 3\u00a0months and 1\u00a0year did not differ significantly between the two groups. Compared with p.o. treatment, i.v. administration of high TAC concentration did not have beneficial post\u2010transplant effects on ACR incidence and severity, while increasing the incidence of viral infections in pediatric LT.<\/jats:p>","DOI":"10.1111\/petr.13368","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T10:35:36Z","timestamp":1549362936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early post\u2010operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-8314","authenticated-orcid":false,"given":"Tarek Abdelazeem","family":"Sabra","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of General Surgery, Pediatric Surgery Unit, Graduate School of Medicine Assiut University Assiut Egypt"},{"name":"Al\u2010Rajhi Liver Institute Assiut University Hospitals Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4043-1070","authenticated-orcid":false,"given":"Hideaki","family":"Okajima","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation, Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation, Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation, Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation, Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abdelkader","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Pediatric Surgery Unit, Graduate School of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser","family":"Saad\u2010Eldin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Graduate School of Medicine Alexandria University Alexandria 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