{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:15Z","timestamp":1753879275028,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>JMML is an aggressive hematopoietic malignancy of early childhood, and allogeneic HSCT is the only curative treatment for this disease. Umbilical cord blood is one of donor sources for HSCT in JMML patients who do not have an HLA\u2010compatible relative, but engraftment failure remains a major problem. Here, we report two cases of JMML who were successfully rescued by HSCT from an HLA\u2010mismatched parent after development of primary engraftment failure following unrelated CBT. Both patients had severe splenomegaly and underwent unrelated CBT from an HLA\u2010mismatched donor. Immediately after diagnosis of engraftment failure, both patients underwent HSCT from their parent. For the second HSCT, we used RIC regimens consisting of FLU, CY, and a low dose of rabbit ATG with or without TBI and additionally administered ETP considering their persistent severe splenomegaly. Both patients achieved engraftment without severe treatment\u2010related adverse effects. After engraftment of second HSCT, their splenomegaly was rapidly regressed, and both patients showed no sign of relapse for over 4\u00a0years. These observations demonstrate that HSCT from an HLA\u2010mismatched parent could be a feasible salvage treatment for primary engraftment failure in JMML patients.<\/jats:p>","DOI":"10.1111\/petr.13378","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T19:29:54Z","timestamp":1550690994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful hematopoietic stem cell transplantation from an HLA\u2010mismatched parent for engraftment failure after unrelated cord blood transplantation in patients with juvenile myelomonocytic leukemia: Report of two cases"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-1281","authenticated-orcid":false,"given":"Koshi","family":"Akahane","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-8111","authenticated-orcid":false,"given":"Atsushi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Furuichi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinpei","family":"Somazu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine University of Yamanashi Yamanashi 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