{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:40:33Z","timestamp":1773031233587,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>CAV is a major cause of mortality in PHTx patients. Research on echocardiographic indices to detect CAV focuses primarily on ventricular function and less is known about RAF. Thus, we primarily sought to evaluate RAF in PHTx patients with CAV. For secondary analysis, we compared RAF between PHTx patients and control patients and evaluated RAF with respect to rejection and surgical type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated echocardiography derived RA strain indices in recipients &lt;18\u00a0years old and &gt;1\u00a0year from time of transplant. The RA strain phases included, reservoir (\u03b5s), conduit (\u03b5e), pump (\u03b5a), and respective strain rate indices (SRs, SRe, SRa).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 36 PHTx patients and 14 age\u2010, sex\u2010matched control patients. There was a significant reduction in \u03b5s, \u03b5e, SRs, and SRe (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in the PHTx patients when compared to controls. There was no difference between the CAV (+) and CAV (\u2212) patients with respect to RAF indices. Furthermore, \u03b5s, \u03b5e, and SRe (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) were lower in patients with acute rejection (n\u00a0=\u00a07) compared to those without (n\u00a0=\u00a026). Patients with a bi\u2010atrial anastomosis (n\u00a0=\u00a014) had decreased \u03b5s, \u03b5a, SRs, SRa (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), compared to bi\u2010caval anastomosis (n\u00a0=\u00a024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PHTx patients have decreased RAF compared to healthy children. RAF does not differentiate PHTx patients based on the presence of CAV. RAF is also decreased in PHTx patients with rejection and in those transplanted with a bi\u2010atrial anastomosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13383","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T21:51:02Z","timestamp":1552513862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Right atrial function in pediatric heart transplant patients by echocardiographic strain measurements"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2085-4623","authenticated-orcid":false,"given":"Kae","family":"Watanabe","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics University of Colorado School of Medicine and Children\u2019s Hospital Colorado Aurora Colorado"},{"name":"Division of Cardiology, Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago 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