{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:32:32Z","timestamp":1774963952957,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In areas of the world where human herpesvirus 8 (HHV\u20108) is endemic, Kaposi sarcoma (KS) is a common SOT\u2010associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11\u00a0months. The donor was a male with no known history of KS, originally from an HHV\u20108\u2010endemic country. Three months after transplantation, the patient developed liver nodules and portal vein thrombosis. Analysis of needle biopsy established the diagnosis of KS and confirmed that the transformed cells were donor\u2010derived. HHV\u20108 viremia was detected, and ganciclovir dosing (which had been started prophylactically) was increased. Immunosuppression was changed from tacrolimus to sirolimus. After further disease progression, 8 cycles of paclitaxel were administered. Under this treatment, her nodules regressed, HHV\u20108 viremia resolved, and she had marked clinic improvement. Notably, the adult recipient of the right liver lobe from the same donor also developed PTKS. This is one of few pediatric PTKS cases described in the literature. It contributes to the mechanistic understanding of PTKS development, illustrating the risk posed by donors from HHV\u20108\u2010endemic countries, as well as the potential for strong PTKS correlation between multiple recipients of organs from a single shared donor.<\/jats:p>","DOI":"10.1111\/petr.13384","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T07:01:50Z","timestamp":1551942110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pediatric post\u2010transplant hepatic kaposi sarcoma due to donor\u2010derived human herpesvirus 8"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1738-1634","authenticated-orcid":false,"given":"Karen E.","family":"Ocwieja","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara O.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Pathology Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Elisofon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children\u2019s Cancer and Blood Disorders Center Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Fawaz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Collins","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children\u2019s Cancer and Blood Disorders Center Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khashayar","family":"Vakili","sequence":"additional","affiliation":[{"name":"Department of Surgery Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvi S.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31735"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12966"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042831"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01302.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02816.x"},{"issue":"7","key":"e_1_2_6_9_1","first-page":"2826","article-title":"Risk of Kaposi\u2019s sarcoma\u2010associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi\u2019s sarcoma patients","volume":"90","author":"Parravicini 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