{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:54:50Z","timestamp":1768715690187,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T00:00:00Z","timestamp":1554508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["1520210"],"award-info":[{"award-number":["1520210"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of unrelated donor HSCT for children with de novo AML in CR1 is controversial. We performed this study to investigate the feasibility of unrelated donor HSCT who initially had intermediate\u2010 or high\u2010risk cytogenetics. We retrospectively reviewed medical records of patients with AML who received unrelated HSCT in CR1 at Samsung Medical Center between November 2001 and January 2012. Patients were allocated based on karyotype at diagnosis as follows: (a) low\u2010risk: inv(16), t(16;16), t(8;21), and t(15;17); (b) high\u2010risk: \u20105, 5q\u2010, \u20107, 3q abnormalities, t(8;16), t(6;9), t(6;11), t(6;21), t(10;11), complex karyotype (\u22653 abnormalities), and acute megakaryocytic leukemia without t(1;22); and (c) IR: all the other karyotypes including normal. Patients in intermediate\u2010 or high\u2010risk group who were transplanted with either unrelated CB or matched unrelated BM\/mobilized PB in their CR1 were included in this study. The projected OS and EFS rates were 74.9% and 71.1%, respectively, with a median follow\u2010up of 87.3\u00a0months after transplantation. The EFS was 70.1%, 80.7%, and 73.9% for CB, BM, and mobilized PB groups, respectively (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.89), and 73.9% and 70.6% for IR and high\u2010risk groups (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.76). The leading cause of death was relapse (n\u00a0=\u00a08), and only one patient died from non\u2010relapse cause. Unrelated donor HSCT seems a feasible approach for children with intermediate\u2010 or high\u2010risk AML in CR1. Relapse remains the leading cause of treatment failure among these patients.<\/jats:p>","DOI":"10.1111\/petr.13397","type":"journal-article","created":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T05:19:21Z","timestamp":1554614361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unrelated donor hematopoietic stem cell transplantation for pediatric de novo acute myeloid leukemia with intermediate\u2010 or high\u2010risk cytogenetics"],"prefix":"10.1111","volume":"23","author":[{"given":"Eu Gene","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sang","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-8827","authenticated-orcid":false,"given":"Young Bae","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungbuk National University College of Medicine Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Woong","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Hoe","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-7912","authenticated-orcid":false,"given":"Keon 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