{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:37:18Z","timestamp":1768516638611,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, is a potent immunosuppressant that is increasingly used in prevention and treatment of graft\u2010vs\u2010host disease (GVHD) in allogeneic hematopoietic stem cell transplant (HSCT) patients. However, data regarding its adverse effects in HSCT patients remain limited. We describe an 18\u2010year\u2010old HSCT patient with a history of invasive fungal infection, who developed pericardial effusion with cardiac tamponade and interstitial pneumonitis while receiving sirolimus for GVHD prophylaxis. Our case illustrates potentially life\u2010threatening complications of sirolimus use in allogeneic HSCT patients.<\/jats:p>","DOI":"10.1111\/petr.13425","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T08:33:24Z","timestamp":1556008404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sirolimus\u2010associated pericardial effusion with cardiac tamponade and interstitial pneumonitis in a hematopoietic stem cell transplant recipient"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8811-7873","authenticated-orcid":false,"given":"Su Jin","family":"Joo","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases Nationwide Children's Hospital Columbus Ohio"},{"name":"Division of Pediatric Infectious Diseases Department of Pediatrics Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inci","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases Department of Pediatrics Emory University School of Medicine Atlanta Georgia"},{"name":"Rollins School of Public Health, Department of Epidemiology Emory University Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth O.","family":"Stenger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Emory University Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases Department of Pediatrics Emory University School of Medicine Atlanta Georgia"},{"name":"Division of Infectious Diseases, Department of Internal Medicine Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00211-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1709384"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2006.00598.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2016.1132698"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12147"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200109150-00008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/305931"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00356.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a05b7a"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181636061"},{"key":"e_1_2_7_12_1","unstructured":"Food and Drug Administration.Rapamune (sirolimus) tablets label 2010.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2010\/021110s058lbl.pdf. 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