{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:43:23Z","timestamp":1764996203640,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver stiffness measurement by transient elastography is a non\u2010invasive ultrasound\u2010based technique used mainly for the evaluation of liver fibrosis in patients with chronic liver diseases. Some authors have suggested that it could be useful in the assessment of hepatic complications during hematopoietic stem cell transplant (HSCT), especially veno\u2010occlusive disease (VOD) or sinusoidal obstructive syndrome (SOS). Here, we present the evaluation of liver stiffness in three patients who developed severe hepatic VOD\/SOS after HSCT. Liver stiffness measurement values were normal before transplant and afterward until the diagnosis of VOD\/SOS when a dramatic increase was observed. After the VOD\/SOS specific treatment, the values of stiffness showed a similar pattern of progressive reduction in all the three patients, with normalization after two weeks. In this report, we discuss the role of LSM in the management of patients after the diagnosis of VOD\/SOS.<\/jats:p>","DOI":"10.1111\/petr.13456","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T07:23:15Z","timestamp":1557732195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Longitudinal evaluation of liver stiffness in three pediatric patients with veno\u2010occlusive disease"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-5942","authenticated-orcid":false,"given":"Daniele","family":"Zama","sequence":"first","affiliation":[{"name":"Department of Pediatrics, S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Boss\u00f9","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-8585","authenticated-orcid":false,"given":"Federico","family":"Ravaioli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC) University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Masetti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arcangelo","family":"Prete","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Festi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC) University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pession","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1016\/j.bbmt.2015.09.024"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1016\/j.bbmt.2009.08.024"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.7326\/0003-4819-118-4-199302150-00003"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1111\/bjh.13215"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1038\/bmt.2015.52"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1038\/bmt.2011.65"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1038\/bmt.2017.161"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1080\/17474124.2019.1588111"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1055\/a-0641-0076"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1038\/bmt.2014.61"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1038\/bmt.2016.320"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"Using liver elastography to diagnose sinusoidal obstruction syndrome in pediatric patients undergoing hematopoetic stem cell transplant","volume":"15","author":"Reddivalla N","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_8_14_1","first-page":"S1083-8791(19)3","article-title":"Liver stiffness measurement allows early diagnosis of veno\u2010occlusive disease\/sinusoidal obstruction syndrome in adult patients who undergo hematopoietic stem cell transplantation: results from a monocentric prospective study","author":"Colecchia A","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1016\/j.bbmt.2010.02.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1182\/blood.V120.21.738.738","article-title":"Results of a large prospective study on the use of defibrotide (DF) in the treatment of hepatic veno\u2010occlusive disease (VOD) in hematopoietic stem cell transplant (HSCT). Early intervention improves outcome \u2010 Updated results of a treatment IND (T\u2010IND) expanded access protocol","volume":"120","author":"Richardson PG","year":"2012","journal-title":"Blood"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1038\/bmt.2012.113"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13456","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T04:43:31Z","timestamp":1694321011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,13]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/petr.13456"],"URL":"https:\/\/doi.org\/10.1111\/petr.13456","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2019,5,13]]},"assertion":[{"value":"2018-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13456"}}