{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:22:32Z","timestamp":1773958952526,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN2722011000040C"],"award-info":[{"award-number":["HHSN2722011000040C"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Information about HAdV infection in SOT recipients is limited. We aimed to describe HAdV infection epidemiology and outcomes in a single\u2010center retrospective cohort during the era of PCR availability. SOT recipients transplanted at the CHOP 2004\u20102013 were followed up for 180\u00a0days post\u2010transplant. HAdV infection was defined as a positive HAdV PCR from a clinical specimen. HAdV disease was defined by organ\u2010specific radiologic and\/or laboratory abnormalities. No HAdV surveillance protocols were employed during the study period; testing was solely per clinician discretion. Progression of HAdV infection was defined as HAdV disease or \u22651\u2010log viral load increase since a corresponding site's first positive specimen. Of the assembled 425 SOT recipients, 227 (52.6%) had \u22651 HAdV PCR. Twenty\u2010four (10.6%) had \u22651 HAdV\u2010positive PCR. HAdV\u2010positive subjects were younger than uninfected subjects (2.0\u00a0years vs 6.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Infection incidence rates were highest in liver recipients (15.3%), followed by heart (8.6%), kidney (8.3%), and lung (4.2%). Four subjects (16.7%) met HAdV disease criteria at virus detection. Five subjects (20.8%) had progression of HAdV infection. All\u2010cause mortality rates in positive and negative subjects were 0% and 3.9%, respectively. HAdV infection was infrequently detected in SOT recipients. Over one\u2010third of HAdV\u2010positive patients met disease criteria at detection or had infection progression, but none died. This low all\u2010cause mortality raises questions about benefits of HAdV surveillance. Larger multicenter studies are needed to assess incidence variance by center and comparative effectiveness of therapeutic interventions.<\/jats:p>","DOI":"10.1111\/petr.13510","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T10:48:08Z","timestamp":1560854888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Outcomes of human adenovirus infection and disease in a retrospective cohort of pediatric solid organ transplant recipients"],"prefix":"10.1111","volume":"23","author":[{"given":"Craig L. K.","family":"Boge","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases The Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"Center for Pediatric Clinical Effectiveness The Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases The Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"Center for Pediatric Clinical Effectiveness The Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Petersen","sequence":"additional","affiliation":[{"name":"Infectious Disease Program Lovelace Respiratory Research Institute Albuquerque New Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alix E.","family":"Seif","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Division of Oncology The Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale R.","family":"Purdy","sequence":"additional","affiliation":[{"name":"Center for Pediatric Clinical Effectiveness The Children\u2019s Hospital of Philadelphia Philadelphia 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Philadelphia Pennsylvania"},{"name":"Department of Pathology Perelman School of Medicine at the University of Pennsylvania School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana E.","family":"Kajon","sequence":"additional","affiliation":[{"name":"Infectious Disease Program Lovelace Respiratory Research Institute Albuquerque New 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