{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:19Z","timestamp":1753879159380,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children and adolescents with HL have excellent long\u2010term survival exceeding 95% after combined modality treatment. However, about 20% will either relapse or have PRF. Salvage HDCT followed by AHSCT is considered to be the preferential treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the outcome (OS and EFS) and prognostic factors in pediatric patients with relapsed or refractory HL (r\/rHL) who underwent AHSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included 43 pediatric patients with r\/rHL who underwent AHSCT from July 1, 2007, till December 31, 2016, at the Children's Cancer Hospital of Egypt. MAC regimen given was CMV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the whole cohort, 88.4% of patients achieved CR, while 11.6% had a positive PET scan prior to transplantation. The 3\u2010year OS and EFS were 85% and 70.6%, respectively. The 3\u2010year OS for patients\u00a0&gt;\u00a010\u00a0years was 94% versus 65.5% for patients 10\u00a0years of age or younger (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.046). There is strong tendency toward better 3\u2010year OS for patients with negative PET scan as compared to those with positive PET scan before AHSCT, 89.4% vs 60%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.059). This tendency is also applicable when looking at the 3\u2010year EFS for the two groups, 78.3% vs 40%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.069).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Poor predictors of OS were younger age and positive PET scan before AHSCT. The latter, along with single modality treatment before AHSCT, were poor predictors of EFS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13531","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T17:11:07Z","timestamp":1562260267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcome predictors of autologous hematopoietic stem cell transplantation in children with relapsed and refractory Hodgkin lymphoma: Single\u2010center experience in a lower\u2010middle\u2010income country"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1573-5483","authenticated-orcid":false,"given":"Amr","family":"Abdalla","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology and Stem Cell Transplantation Unit Children Cancer Hospital Egypt (CCHE\u201057357) Cairo Egypt"},{"name":"Department of Pediatric Oncology and Stem Cell Transplantation 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