{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:43:35Z","timestamp":1764996215325,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T00:00:00Z","timestamp":1562371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010Cy administration for GVHD prophylaxis in unmanipulated haploidentical HSCT has resulted in improved outcomes in recent years. Studies in children are lacking and accordingly we present the outcomes of 62 haploidentical transplantation for high\u2010risk children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We retrospectively assessed 62 transplants in 60 patients who underwent haploidentical\u2010related HSCT with unmanipulated stem cells and for whom Post\u2010Cy was used for GVHD prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Myeloid reconstitution was achieved on day\u00a0+\u00a030 for 57 of the 62 patients. The median follow\u2010up of the surviving 39 patients (63%) was 26\u00a0months, with a range of 6\u201057\u00a0months. The OS and EFS at 2\u00a0years were 64.6% (52.0%\u201077.2%, 95% CI) and 58.9% (46.1%\u201071.7%, 95% CI), respectively. The only factor in our multivariate analysis that contributed to an inferior EFS was a poor remission status prior to HSCT (HR, 8.30; 1.08\u201063.56; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.041, 95% CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of T\u2010cell replete haploidentical transplantation with Post\u2010Cy GVHD prophylaxis in high\u2010risk pediatric patients are promising. However, further research is needed to determine the factors that have affect HLA compatibility for predicting the success of haploidentical transplantations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13546","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T07:53:55Z","timestamp":1562399635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Haploidentical hematopoietic stem cell transplantation with post\u2010transplant high\u2010dose cyclophosphamide in high\u2010risk children: A single\u2010center study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3257-7798","authenticated-orcid":false,"given":"Vedat","family":"Uygun","sequence":"first","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation Unit MedicalPark Antalya Hospital Antalya 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