{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:11:53Z","timestamp":1790615513632,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Temporal changes in kidney transplant outcomes for cystinosis are unknown. We used the SRTR to identify all kidney transplants performed for cystinosis in patients younger than 31\u00a0years between 1987 and 2017. We divided time into three equal eras (1987\u20101997, 1998\u20102007, and 2008\u20102017) to assess changes in outcomes using Cox proportional and linear regression models. We examined 441 transplants in 362 patients. Age at ESRD progressively increased (12.1 vs 13.3 vs 13.4; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.046). Eras 2 and 3 had lower risk of acute rejection (aHR 2 vs 1:0.45; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) (aHR 3 vs 1:0.26; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and higher 5\u2010year mean GFR (difference 2 vs 1:9.2\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) (difference 3 vs 1:12.9\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) compared with era 1. Five\u2010year graft survival was similar across eras, but 5\u2010year patient survival was higher for era 2 (aHR: 0.25; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Seventy\u2010nine patients underwent retransplantation. Five\u2010year patient (94.2% vs 92.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.57) and graft survival (79.1% vs 74.1%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.52) were similar between primary and subsequent transplants. Age at ESRD, acute rejection, GFR at 5\u00a0years, and patient survival improved over time. Kidney retransplantation is associated with excellent outcomes in children and young adults with cystinosis.<\/jats:p>","DOI":"10.1111\/petr.13572","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T06:59:57Z","timestamp":1568357997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Trends in kidney transplant outcomes in children and young adults with cystinosis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-7856","authenticated-orcid":false,"given":"Sarah J.","family":"Kizilbash","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7974-8940","authenticated-orcid":false,"given":"Jon","family":"Snyder","sequence":"additional","affiliation":[{"name":"Scientific Registry of Transplant Recipients Minneapolis Medical Research Foundation Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-9579","authenticated-orcid":false,"given":"David M.","family":"Vock","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanche M.","family":"Chavers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Minnesota Minneapolis 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