{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:54:36Z","timestamp":1761630876204,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Literature is limited comparing induction immunosuppression in pediatric liver transplant (LTx) recipients. This is a single\u2010center, retrospective cohort study of primary pediatric liver transplants at our center between 2005 and 2016 who received either basiliximab (BSX) or rabbit anti\u2010thymocyte globulin (rATG) induction. Maintenance immunosuppression consisted of tacrolimus\u00a0\u00b1\u00a0a corticosteroid taper. Exclusions included receipt of an ABO\u2010incompatible graft, retransplantation, and multi\u2010organ transplantation. Primary outcomes were incidence of treated biopsy\u2010proven acute rejection (tBPAR) and PTLD within the first year and infections within 90\u00a0days of LTx. Secondary outcomes included graft and patient survival, time to first tBPAR, and incidence of steroid\u2010resistant rejection (SRR) within the first year post\u2010LTx. A total of 136 patients were included in the final analysis of which 57 patients (42%) received BSX induction. Patients who received rATG induction with or without a 2\u2010week corticosteroid taper experienced significantly more tBPAR compared to those who received BSX induction with a 6\u2010month corticosteroid taper (55.7% vs 33.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). There were no differences in the incidence of PTLD, infections, SRR, graft or patient survival, or time to first tBPAR between the two groups<jats:bold>. <\/jats:bold>Induction with rATG either with or without a short corticosteroid taper was associated with significantly more tBPAR in primary pediatric LTx recipients when compared to BSX induction with a prolonged corticosteroid taper in the setting of maintenance immunosuppression with tacrolimus.<\/jats:p>","DOI":"10.1111\/petr.13573","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T09:39:41Z","timestamp":1568281181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of rabbit anti\u2010thymocyte globulin vs basiliximab induction in pediatric liver transplant recipients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-8065","authenticated-orcid":false,"given":"David M.","family":"Newland","sequence":"first","affiliation":[{"name":"Department of Pharmacy Seattle Children's Hospital Seattle WA USA"},{"name":"School of Pharmacy University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7041-1329","authenticated-orcid":false,"given":"Macy J.","family":"Royston","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Seattle Children's Hospital Seattle WA USA"},{"name":"School of Pharmacy University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6215-7765","authenticated-orcid":false,"given":"Derry R.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Seattle Children's Hospital Seattle WA USA"},{"name":"School of Pharmacy University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Seattle Children's Hospital Seattle WA USA"},{"name":"School of Pharmacy University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Wallace\u2010Boughter","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery Seattle Children's Hospital Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Carlin","sequence":"additional","affiliation":[{"name":"Children's Core for Biomedical Statistics Seattle Children's Research Institute Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5949-7363","authenticated-orcid":false,"given":"Simon","family":"Horslen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Washington School of Medicine Seattle WA USA"},{"name":"Department of Gastroenterology Hepatology and Nutrition Seattle Children's Hospital Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15276"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23697"},{"key":"e_1_2_10_4_1","unstructured":"Simulect\u00a9 prescribing information.East Hanover NJ:Novartis Pharmaceuticals Corporation.2005."},{"key":"e_1_2_10_5_1","unstructured":"Thymoglobulin\u00a9 prescribing information.Cambridge MA:Genzyme Corporation.2017."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13909"},{"volume-title":"Lexi\u2010Drugs","author":"Basiliximab","key":"e_1_2_10_7_1"},{"volume-title":"Lexi\u2010Drugs","author":"Antithymocyte Globulin (Rabbit)","key":"e_1_2_10_8_1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00797.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20896"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01406.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21397"},{"key":"e_1_2_10_13_1","first-page":"425","article-title":"Superior patient and graft survival in adult liver transplant with rabbit antithymocyte globulin induction: experience with 595 patients","volume":"4","author":"Montenovo M","year":"2017","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v5.i4.261"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016647974"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2002.01086.x"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T08:12:48Z","timestamp":1694247168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,12]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/petr.13573"],"URL":"https:\/\/doi.org\/10.1111\/petr.13573","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2019,9,12]]},"assertion":[{"value":"2019-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13573"}}