{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:29:06Z","timestamp":1771457346845,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>X\u2010linked agammaglobulinemia (XLA) is a primary antibody disorder due to a mutation in the Bruton tyrosine kinase gene that requires lifelong immunoglobulin replacement resulting in a significant economic burden and treatment abandonment. Hematopoietic stem cell transplantation (HSCT) offers an alternative option for complete cure. In our series, two children with XLA underwent successful HSCT using a myeloablative conditioning with thiotepa, treosulfan, and fludarabine from a matched sibling donor. The second child had rejected his first graft following a busulfan\u2010based regimen with resultant autologous reconstitution. At 6\u00a0months post\u2010HSCT, serum IgG were normal, off IVIG, and had no infections. Both children after a median follow\u2010up of 20\u00a0months have 100% chimerism. Treosulfan\u2010based reduced toxicity myeloablative HSCT has encouraging results with a positive impact on the socioeconomics in developing countries.<\/jats:p>","DOI":"10.1111\/petr.13625","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T15:25:01Z","timestamp":1575991501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Treosulfan\u2010based reduced toxicity hematopoietic stem cell transplantation in X\u2010linked agammaglobulinemia: A cost\u2010effective alternative to long\u2010term immunoglobulin replacement in developing countries"],"prefix":"10.1111","volume":"24","author":[{"given":"Venkateswaran","family":"Vellaichamy Swaminathan","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai 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