{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:01:28Z","timestamp":1777021288205,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malnutrition is common among children with single ventricle (SV) congenital heart disease (CHD). The impact of heart transplantation (HT) on nutritional status in SV patients is understudied. Our aim was to evaluate anthropometric changes in SV patients after HT, compared with those transplanted for cardiomyopathy (CM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center retrospective chart review of SV and CM patients\u00a0&lt;\u00a018\u00a0years who underwent HT from January 01, 2010 to December 05, 2017. Wasting and stunting were defined as z\u2010scores for weight\u2010for\u2010age or height\u2010for\u2010age \u2264\u20102, respectively. Changes in these indices between HT and 3\u00a0years post\u2010HT were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 86 eligible patients, 28 (33%) had SV CHD and 58 (67%) had CM. Data were available at 3\u00a0years post\u2010HT for 57 patients. At transplant, wasting was equally present in SV versus CM patients (7\/28, 25% vs. 9\/58, 16%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.22), which remained true at 3\u00a0years post\u2010HT (2\/16, 13% vs. 3\/41, 7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.61). At transplant, stunting was more common in SV than CM patients (17\/28, 61% vs. 8\/58, 14%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). At 3\u00a0years post\u2010HT, 6 of 16 (38%) SV patients and 3 of 41 (7%) CM patients remained stunted (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Among all patients, wasting decreased from transplant to end\u2010point (19% vs. 9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05), but stunting did not (29% vs. 16%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.2), such that wasting and stunting were associated at transplant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) but not at end\u2010point (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.17).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longitudinal growth remains impaired for several years after HT in SV patients, even when weight gain is achieved, suggesting that some factors contributing to growth impairment persist despite resolution of SV physiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13634","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T07:01:45Z","timestamp":1576566105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Growth stunting in single ventricle patients after heart transplantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-6848","authenticated-orcid":false,"given":"Alyssa","family":"Power","sequence":"first","affiliation":[{"name":"Department of Pediatrics (Cardiology) Stanford University Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Schultz","sequence":"additional","affiliation":[{"name":"Nutrition Services Lucile Packard Children\u2019s Hospital Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelin","family":"Dennis","sequence":"additional","affiliation":[{"name":"Nutrition Services Lucile Packard Children\u2019s Hospital Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Rizzuto","sequence":"additional","affiliation":[{"name":"Rehabilitation Services Lucile Packard Children\u2019s Hospital Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"Hollander","sequence":"additional","affiliation":[{"name":"Rehabilitation Services Lucile Packard Children\u2019s Hospital Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Cardiology) Stanford University Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S.","family":"Almond","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Cardiology) Stanford University Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-3150","authenticated-orcid":false,"given":"Seth A.","family":"Hollander","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Cardiology) Stanford University Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12141"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000189"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.12.041"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70146-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00625.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2009405"},{"issue":"3","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1542\/peds.86.3.368","article-title":"Enteral nutrition in infants with congenital heart disease and growth failure","volume":"86","author":"Schwarz SM","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.01.003"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"279","article-title":"Serum IGF\u20101, IGFBP\u20103 and growth hormone levels in children with congenital heart disease: relationship with nutritional status, cyanosis and left ventricular functions","volume":"28","author":"Dinleyici EC","year":"2007","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951100008118"},{"issue":"270","key":"e_1_2_8_12_1","first-page":"e6","article-title":"Assessment of growth 6 years after the Norwood procedure","volume":"180","author":"Burch PT","year":"2017","journal-title":"J Pediatr"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12352"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.01.026"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx456"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533612457948"},{"key":"e_1_2_8_17_1","volume-title":"The A.S.P.E.N. Pediatric Nutrition Support Handbook","author":"Corkins MR","year":"2015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941406413518491"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13351"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00172-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.10.1262"},{"issue":"5","key":"e_1_2_8_23_1","first-page":"V43","article-title":"Cardiac transplantation in children and adolescents","volume":"76","author":"Starnes VA","year":"1987","journal-title":"Circulation"},{"issue":"5","key":"e_1_2_8_24_1","first-page":"848","article-title":"Session VII: Physiologic and psychological growth and development in pediatric heart transplant recipients","volume":"10","author":"Baum MF","year":"1991","journal-title":"J Heart Lung Transplant"},{"issue":"4","key":"e_1_2_8_25_1","first-page":"441","article-title":"Heart transplantation in children","volume":"4","author":"Pennington DG","year":"1985","journal-title":"J Heart Transplant"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02125805"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-3046.2003.00123.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00172-8"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.05.001"},{"issue":"3","key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"e000079","DOI":"10.1161\/JAHA.114.000079","article-title":"Longitudinal assessment of growth in hypoplastic left heart syndrome: results from the Single Ventricle Reconstruction Trial","volume":"23","author":"Burch PT","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.05.051"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008771"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4268"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353633"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.937995"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12555"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12773"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmp036"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/32403"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1178-5"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135115598212"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1265-7"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13634","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:11:19Z","timestamp":1694160679000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,16]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/petr.13634"],"URL":"https:\/\/doi.org\/10.1111\/petr.13634","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,16]]},"assertion":[{"value":"2019-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13634"}}