{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:43Z","timestamp":1753879363587,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatic VOD is a potentially fatal complication during stem cell transplantation and is rarely seen in the non\u2010transplant setting. We report the case of a five\u2010year\u2010old boy who presented with visual complaints during delayed intensification phase of treatment for ALL. He was found to have bilateral retinal hemorrhages associated with profound thrombocytopenia due to chemotherapy. VOD was diagnosed based on EBMT criteria and was managed with supportive care. Despite resolution of VOD, his vision progressively deteriorated and resulted in blindness. This case highlights the significance of close monitoring of ALL patients in delayed intensification when they are at risk for developing VOD, the importance of refractory thrombocytopenia as a diagnostic feature and the potential for VOD to manifest with intraocular bleeding.<\/jats:p>","DOI":"10.1111\/petr.13638","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T06:55:51Z","timestamp":1576479351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ocular hemorrhage secondary to thioguanine\u2010associated veno\u2010occlusive disease in a child with acute lymphoblastic leukemia in delayed intensification"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-5783","authenticated-orcid":false,"given":"Nabanita","family":"Bhunia","sequence":"first","affiliation":[{"name":"Pediatric Hematology, Oncology and Bone Marrow Transplantation Nationwide Children\u2019s Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas D.","family":"Yeager","sequence":"additional","affiliation":[{"name":"Pediatric Hematology, Oncology and Bone Marrow Transplantation Nationwide Children\u2019s Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan I.","family":"Colace","sequence":"additional","affiliation":[{"name":"Pediatric Hematology, Oncology and Bone Marrow Transplantation Nationwide Children\u2019s Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Buzzaco","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajinder P. S.","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Pediatric Hematology, Oncology and Bone Marrow Transplantation Nationwide Children\u2019s Hospital Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.161"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/11531840-000000000-00000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-230656"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3453-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61938-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040121"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12558"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.08.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12072"},{"issue":"5","key":"e_1_2_7_11_1","first-page":"275","article-title":"Why is it necessary to examine retina when the patient suffers from aplastic anemia?","volume":"119","author":"Tomcikova D","year":"2018","journal-title":"Bratisl Lek Listy"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13638","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:11:29Z","timestamp":1694160689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,15]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/petr.13638"],"URL":"https:\/\/doi.org\/10.1111\/petr.13638","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2019,12,15]]},"assertion":[{"value":"2019-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13638"}}