{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:52:32Z","timestamp":1788803552608,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Steroid avoidance in pediatric kidney transplants was found effective with extended daclizumab induction. Upon discontinuation of daclizumab, lymphocyte\u2010depleting agents became used, with little comparative data. We assessed outcomes in children undergoing low immunologic\u2010risk deceased donor (DD) kidney transplants using induction with antithymocyte globulin (ATG) compared to alemtuzumab. We reviewed consecutive DD kidney transplants from January 2015 to September 2017 at two pediatric centers that used different lymphocyte\u2010depleting agents in steroid\u2010avoidance protocols: ATG (Center A) and alemtuzumab (Center B), with tacrolimus and MMF as maintenance immunosuppression\n                    <jats:bold>.<\/jats:bold>\n                    Anti\u2010infective prophylaxis was based on center protocol. Over the first year post\u2010tx, there were similar rates of infections. EBV and BK viremia were comparable though Center A manifested more low\u2010grade CMV viremia (A 46% vs B 0%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0009) at median onset 1.8\u00a0months, followed by early seroconversion. Reduction of immunosuppression did not differ between groups. DSA at 1\u00a0year was similar (A 8% vs 13%) with low rates of BPAR. Need for steroid\u2010based conversion was low. There were no graft losses and no differences in median eGFR at 30, 90, 180, and 365\u00a0days. (a) 1\u2010year graft outcomes are excellent in steroid\u2010avoidance regimens using ATG or alemtuzumab induction; (b) conversion to steroid\u2010based therapy is low; (c) alemtuzumab\/high\u2010dose MMF is associated with lower WBC and more GCSF use; (d) alemtuzumab\/higher dose MMF results in more diarrhea and azathioprine conversion than ATG\/lower dose MMF; (e) CMV viremia is seen more often with ATG use with infection prophylaxis reduction; however, seroconversion occurs promptly.\n                  <\/jats:p>","DOI":"10.1111\/petr.13685","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T05:04:04Z","timestamp":1582952644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Early outcomes comparing induction with antithymocyte globulin vs alemtuzumab in two steroid\u2010avoidance protocols in pediatric renal transplantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6988-8533","authenticated-orcid":false,"given":"Dechu P.","family":"Puliyanda","sequence":"first","affiliation":[{"name":"Pediatric Nephrology and Transplant Immunology Cedars\u2010Sinai Medical Center Los Angeles California United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Pizzo","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology and Transplant Immunology Cedars\u2010Sinai Medical Center Los Angeles California United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Rodig","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J. G.","family":"Somers","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050410"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04145.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000092950.54184.67"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200107150-00006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.00928.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00735.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03047.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13270"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404683"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12374"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181fc8937"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001416"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00879.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12941"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12253"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12532"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b4acfb"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01448.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14169"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15236"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040360"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12965"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3113-7"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050020"},{"issue":"1","key":"e_1_2_9_27_1","first-page":"91","article-title":"Mycophenolate mofetil in pediatric renal transplantation","volume":"55","author":"Weber LT","year":"2003","journal-title":"Minerva Urol Nefrol"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13685","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T06:48:25Z","timestamp":1693378105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,29]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/petr.13685"],"URL":"https:\/\/doi.org\/10.1111\/petr.13685","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,29]]},"assertion":[{"value":"2019-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13685"}}