{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:31:08Z","timestamp":1788802268205,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>TGF\u2010\u03b21 is a cytokine with profibrogenic and immunosuppressive activities, which suggest the clinical significance of TGF\u2010\u03b21 for the assessment of graft function after LT. We analyzed the dynamics of TGF\u2010\u03b21 levels in the blood after LDLT in 135 pediatric liver recipients and examined the relationship between the cytokine levels and the laboratory and clinical variables. We found that TGF\u2010\u03b21 levels in the blood of patients with ESLD were lower than that in healthy children of the same age, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001. Moreover, blood levels of TGF\u2010\u03b21 were associated with liver disease etiology (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.23) and hepatic fibrosis severity (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.33). Before LDLT, TGF\u2010\u03b21 levels were significantly higher in children with good outcomes than in recipients who developed graft dysfunction early in the post\u2010transplant period, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.047. One month after LDLT, TGF\u2010\u03b21 levels in blood plasma increased in pediatric recipients, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002. Cytokine levels were significantly correlated with gender (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.21) and HLA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.24) mismatches, as well as with TAC dosage (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.32) later in the post\u2010transplant period. One year after LDLT, TGF\u2010\u03b21 plasma levels were higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) than those before LDLT and did not correlate with most of the investigated biochemical and clinical variables. Conclusion: Blood levels of TGF\u2010\u03b21 are associated with hepatic fibrosis severity, graft dysfunction development, and TAC dosage and can be regarded as a potential prognostic biomarker for the assessment of graft function and the optimization of immunosuppressant dosage in pediatric recipients after LDLT.<\/jats:p>","DOI":"10.1111\/petr.13693","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T18:32:30Z","timestamp":1584729150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transforming growth factor beta 1 levels in the blood of pediatric liver recipients: Clinical and biochemical correlations"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-1086","authenticated-orcid":false,"given":"Rivada","family":"Kurabekova","sequence":"first","affiliation":[{"name":"V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3965-5277","authenticated-orcid":false,"given":"Olga","family":"Tsirulnikova","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0871-429X","authenticated-orcid":false,"given":"Irina","family":"Pashkova","sequence":"additional","affiliation":[{"name":"V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3475-3161","authenticated-orcid":false,"given":"Olga","family":"Gichkun","sequence":"additional","affiliation":[{"name":"V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation Moscow Russia"},{"name":"I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4841-7070","authenticated-orcid":false,"given":"Natalia","family":"Mozheyko","sequence":"additional","affiliation":[{"name":"V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-678X","authenticated-orcid":false,"given":"Sergey","family":"Gautier","sequence":"additional","affiliation":[{"name":"V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation Moscow Russia"},{"name":"I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-6465","authenticated-orcid":false,"given":"Olga","family":"Shevchenko","sequence":"additional","affiliation":[{"name":"V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation Moscow Russia"},{"name":"I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"54","article-title":"Liver transplantation in children: six\u2010year experience analysis","author":"Gautier SV","year":"2014","journal-title":"Vestnik transplantologii i iskusstvennykh organov"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i18.4438"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318198d092"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04035.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24730"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1273rev"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090737"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4816-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27609"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0063-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23458"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.801"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2017.05.040"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2784-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v4.i2.133"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12161"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/381215"},{"key":"e_1_2_9_21_1","first-page":"273","volume-title":"Immunosupression at Solid Organ Transplantation","author":"Tsirulnikova OM","year":"2011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010511"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421807"},{"key":"e_1_2_9_24_1","first-page":"263","article-title":"Circulating VEGF and TGF\u2010beta1 in children with idiopathic nephrotic syndrome","volume":"14","author":"Cheong HI","year":"2001","journal-title":"J Nephrol"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40819.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22984"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21430"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199809000-00023"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.01003.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100375"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.06.001"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2001.00314.x"},{"key":"e_1_2_9_33_1","first-page":"229","article-title":"Serum concentration of transforming growth factor (TGF)\u2010beta 1 does not predict advanced liver fibrosis in children with chronic hepatitis B","volume":"51","author":"Lebensztejn DM","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023218"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-015-0023-5"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.5.465"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21491"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2012.12.008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0339"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01389.x"},{"key":"e_1_2_9_41_1","first-page":"15","article-title":"Prognostic value of soluble CD40 ligand after liver transplantation in children with congenital and hereditary diseases of hepatobiliary system","author":"Shevchenko OP","year":"2012","journal-title":"Vestnik transplantologii i iskusstvennykh organov"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12482"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02300.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22480"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000207"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i4.1061"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.06.015"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2437"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i34.7676"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.53"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-017-8944-9"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13693","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:48:04Z","timestamp":1693392484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,20]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/petr.13693"],"URL":"https:\/\/doi.org\/10.1111\/petr.13693","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,20]]},"assertion":[{"value":"2019-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13693"}}