{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:36Z","timestamp":1753879416052,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although poor long\u2010term graft survival in LT in AYA is recognized, detailed epidemiological data are still lacking. L\u2010TCMR may have poor outcomes. This study aimed to provide a detailed, epidemiological assessment of the association between AYA age and rejection. L\u2010TCMR was defined in this study as TCMR with central vein or perivenular inflammation occurring later than 3\u00a0months after LT. A total of 342 patients who survived for at least 3\u00a0months after LT between 2005 and 2015 were enrolled. The AYA group (10\u201024\u00a0years) was compared with the C group (less than 10\u00a0years), and the incidence and outcomes of L\u2010TCMR were analyzed. In total, 342 patients had LT; 38 of these were AYA with the mean follow\u2010up period of 6.7\u00a0years. A total of 304 patients in C group had a mean follow\u2010up period of 6.3\u00a0years (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.28). The incidence of L\u2010TCMR in AYA group was significantly higher than in C group (15.8% vs 4.6%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.006). The time to L\u2010TCMR after LT was significantly shorter in AYA group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Neither patient survival nor the incidence of non\u2010adherence differed significantly between the groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.18 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.89). The number of additional immunosuppressants after L\u2010TCMR was significantly higher in the AYA group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). A high incidence of L\u2010TCMR was observed in AYA group irrespective of non\u2010adherence. AYA patients with L\u2010TCMR should be followed carefully due to the poor results of post\u2010treatment biopsy and the need for intensive immunosuppressive therapy.<\/jats:p>","DOI":"10.1111\/petr.13708","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T11:03:11Z","timestamp":1587812591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Late T cell\u2013mediated rejection may contribute to poor outcomes in adolescents and young adults with liver transplantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8316-3523","authenticated-orcid":false,"given":"Masahiro","family":"Takeda","sequence":"first","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development Tokyo 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