{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:07:03Z","timestamp":1777619223877,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T00:00:00Z","timestamp":1589068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eplet incompatibility appears to be a better predictor of the de novo appearance of DSA post\u2010Tx than HLA antigen matching in adults. We evaluated the HLA Matchmaker\u00ae software (version 2.1) in our pediatric cohort to predict the appearance of DSA post\u2010Tx. We included 70 pediatric patients (26 girls, 10 living donors, mean age 11.2\u00a0\u00b1\u00a03.9\u00a0years) after a first R\u2010Tx (January 2010\u2010August 2016), without prior immunization, having complete HLA typing (A, B, C, DRB1 and DQB1) and DSA follow\u2010up for at least one year. The mean of HLA and eplet incompatibilities was 4.7\u00a0\u00b1\u00a01.3 and 15.5\u00a0\u00b1\u00a06.1, respectively, with a correlation coefficient <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> between these two variables of 0.34 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The eplet load was 12.8\u00a0\u00b1\u00a05.0 in living donors vs 15.9\u00a0\u00b1\u00a06.2 in deceased donors (<jats:italic>P<\/jats:italic>\u00a0=\u00a0NS), 12.6\u00a0\u00b1\u00a06.1 in preemptive R\u2010Tx (n\u00a0=\u00a014) vs 16.3\u00a0\u00b1\u00a05.9 for non\u2010preemptive R\u2010Tx (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Seven patients (10%) developed DSA during the 3.5\u00a0\u00b1\u00a01.2\u00a0years post\u2010Tx. The eplet load was 13.7\u00a0\u00b1\u00a05.5 for those who developed DSA vs 15.7\u00a0\u00b1\u00a06.1 for the others (<jats:italic>P<\/jats:italic>\u00a0=\u00a0NS). In our single\u2010center series of pediatric R\u2010Tx with good HLA matching and lower eplet load than previously published series, eplet incompatibilities do not predict the development of DSA. The question of the HLA matching requirement and the daily interest of the HLA Matchmaker\u00ae software to help select the grafts remain open.<\/jats:p>","DOI":"10.1111\/petr.13721","type":"journal-article","created":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T12:24:35Z","timestamp":1589113475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Eplet incompatibility in pediatric renal transplantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2904-1810","authenticated-orcid":false,"given":"Andreea Liana","family":"R\u00e3chi\u015fan","sequence":"first","affiliation":[{"name":"Department of Pediatrics II University of Medicine &amp; Pharmacy \u00abIuliu Hatieganu\u00bb Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospice Civils de Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Ranchin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Hopital Femme\u2010Mere\u2010Enfant Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Laure","family":"Sellier\u2010Leclerc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Hopital Femme\u2010Mere\u2010Enfant Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelia","family":"Bertholet Thomas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Hopital Femme\u2010Mere\u2010Enfant Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Cochat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Hopital Femme\u2010Mere\u2010Enfant Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Hopital Femme\u2010Mere\u2010Enfant Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.81"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04013.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13192"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000120385.03278.28"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31817441d6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.06.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2012.01654.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017030287"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14393"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000632"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12762"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12815"}],"container-title":["Pediatric 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