{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:35:42Z","timestamp":1784039742986,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14411950600"],"award-info":[{"award-number":["14411950600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008235","name":"School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Killer Ig\u2010like receptor 2DS4 (KIR2DS4) is the most prevalent activating killer Ig\u2010like receptor gene. It is divergent and encodes either full\u2010length or deleted allele variants. The studies of donor killer KIR2DS4 in unrelated allogeneic hematopoietic stem cell transplantations were limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>KIR and HLA genotyping were determined in 75 pairs of Chinese pediatric hematologic malignancy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 75 donor\u2010recipient pairs, 77.3% (58\/75) of the donors were positive for full\u2010length KIR2DS4 and 22.7% (17\/75) were negative. Patients who had donors positive for full\u2010length KIR2DS4 had higher cumulative incidence of aGVHD than patients whose donor negative for full\u2010length KIR2DS4 (86.2% versus 76.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.038). Multivariate analysis showed full\u2010length KIR2DS4 was the significant factor for I\u2010IV aGVHD (HR\u00a0=\u00a02.166, 95% CI: 1.01\u20104.26, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.025). Subgroup analysis showed that AML and CML patients who received donors negative for full\u2010length KIR2DS4 have a higher cumulative incidences of cGVHD (75% vs 62%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008). There were no significant effects of full\u2010length KIR2DS4 on overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.13), relapse\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.14), CMV reactivation (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.52), and relapse (HR\u00a0=\u00a00.38, 95% CI: 0.09\u20101.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.1875).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicated a significant correlation of donor full\u2010length KIR2DS4 on aGVHD and cGVHD. These results suggested that combining KIR and HLA genotyping may help make a better sense of transplants in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13728","type":"journal-article","created":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T06:58:25Z","timestamp":1593327505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of donor full\u2010length KIR2DS4 in the development of acute and chronic GVHD after unrelated allogeneic HSCT"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4937-4567","authenticated-orcid":false,"given":"Kang","family":"An","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care Unit Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University Shanghai 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