{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:01:41Z","timestamp":1764997301262,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>Several PK studies have shown that most pediatric patients may require higher doses on a mg\/kg basis compared to adults to attain similar therapeutic trough concentrations. The aim of this study was to compare the efficacy and safety of three times daily to twice a day dosing of tacrolimus in pediatric kidney transplant recipients at a major tertiary care transplant center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Retrospective, single\u2010center, and comparative cohort study. All pediatric kidney transplant recipients received either tacrolimus BID (group 1) or tacrolimus TID (group 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 87 patients were included in this study; 48 patients received BID tacrolimus (group 1), and 39 patients received TID tacrolimus (group 2). The percentage of patients who achieved therapeutic trough concentrations in group 2 did not significantly differ from those in group 1 at day 7 (84.62% TID vs 83.33% BID; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.42). The median time to reach therapeutic trough concentrations was three days in group 1 compared to four days in group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No significant difference was observed between tacrolimus BID and TID dosing in the time to reach therapeutic trough concentration or in the proportion of patients achieving therapeutic trough concentrations at day 7.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13733","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T09:23:51Z","timestamp":1590657831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of three times daily dosing of tacrolimus in pediatric kidney transplantation patients: A single\u2010center comparative study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-5165","authenticated-orcid":false,"given":"Zinah","family":"Alabdulkarim","sequence":"first","affiliation":[{"name":"Pharmaceutical Care Division King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-9086","authenticated-orcid":false,"given":"Ahmed","family":"Al\u2010jedai","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Division King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia"},{"name":"Deputyship of Therapeutic Affairs Ministry of Health Riyadh Saudi Arabia"},{"name":"Colleges of Pharmacy and Medicine, Alfaisal University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delal","family":"Alkortas","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Division King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Alhasan","sequence":"additional","affiliation":[{"name":"Kidney &amp; Pancreas Transplantation Department King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia"},{"name":"College of Medicine, King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Devol","sequence":"additional","affiliation":[{"name":"Biostatistics Epidemiology &amp; Scientific Computing Department King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05021107"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"83","article-title":"Symphony: comparing standard immunosuppression to low\u2010dose cyclosporine, tacrolimus or sirolimus in combination with MMF, daclizumab and corticosteroids in renal transplantation","volume":"82","author":"Ekberg H","year":"2006","journal-title":"Transplantation"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067411"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)85038-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2015.01.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03791106"},{"key":"e_1_2_9_8_1","first-page":"119","article-title":"The kidney transplant program at King Faisal Specialist Hospital and Research Center","volume":"19","author":"Al\u2010Meshari K","year":"2005","journal-title":"Clin Transpl"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.050955"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443100-00001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200140040-00004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg1029"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.1996.tb00512.x"},{"key":"e_1_2_9_14_1","first-page":"50","article-title":"Japanese multi\u2010center studies of FK506 in renal transplantation","volume":"27","author":"Ochiai T","year":"1995","journal-title":"Transplant Proc"},{"key":"e_1_2_9_15_1","first-page":"3085","article-title":"Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration","volume":"23","author":"Japanese FK 506 Study Group","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2003.09.009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00592.x"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13733","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T15:59:28Z","timestamp":1693929568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,28]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/petr.13733"],"URL":"https:\/\/doi.org\/10.1111\/petr.13733","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2020,5,28]]},"assertion":[{"value":"2020-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13733"}}